9.B.227.2.4
Phosphatidylglycerol lysyltransferase, MprF of 314 aas and 8 TMSs in a 2 + 2 + 4 TMS arrangement. Catalyzes the transfer of a lysyl group
from L-lysyl-tRNA(Lys) to membrane-bound phosphatidylglycerol (PG),
which produces lysylphosphatidylglycerol (LPG), a major component of the
bacterial membrane with a positive net charge. LPG synthesis
contributes to bacterial virulence as it is involved in the resistance
mechanism against cationic antimicrobial peptides (CAMP) produces by the
host's immune system (defensins, cathelicidins) and by the competing
microorganisms.
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| Accession Number: | U2K2Z7 |
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| Protein Name: | Phosphatidylglycerol lysyltransferase |
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| Length: | 314 |
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| Molecular Weight: | 35623.00 |
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| Species: | Ruminococcus callidus ATCC 27760 [411473] |
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| Number of TMSs: | 8 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MKFLKKYYKL IGTLITVVAF VFVIKKIVTM DVDWSMFASG KPLGIIAGCV LVQTAIIFFM
61: STPWVQFVRI LSGKKIAMKD ALPVYTKCNL MKYVPGNVFQ YVGRNQLAAD LHISHVDVAC
121: ATVLEILCSL VAPLVWILLL MGKDMVGLIR TYEKNFLLVL GIGVAVLVLA FFLLRWKFRE
181: PLRRYFEKYR KLLNRKILLR VVGVFLLYVL QYLFSATMYA VPAFLMFDVP RAQMGLFLGT
241: YLFSWVIGFI TPGAPGGIGV REAVMVLTCS TFLDTNTIML YAVTMRIIST FGDVLAFFLG
301: WLLHLIWKRQ KATA