TCID | Name | Domain | Kingdom/Phylum | Protein(s) |
---|---|---|---|---|
9.B.229.1.1 | The transferrin receptor, TfR or TFRC, of 760 aas and 1 TMS (Recalcati et al. 2017). Optimal conditions for Western blotting for this and other proteins requires that the sample not be boiled (Tsuji 2020). | Eukaryota |
Metazoa | TfR of Homo sapiens |
9.B.229.1.2 | Transferrin receptor-2, TfR2 or TFR2 of 801 aas and 1 TMS. TFR2, is predominantly expressed in hepatocytes and erythroid precursor cells. In the liver, TFR2 forms a complex with HFE, a hereditary hemochromatosis-associated protein, and acts as an iron sensor. In mice, hepatocyte-specific knockout of the TFR2 gene has been shown to cause systemic iron-overload with decreased expression of hepcidin, the central regulator of iron homeostasis. In erythroid cells, TFR2 forms a complex with the erythropoietin receptor and facilitates its trafficking to the cell membrane. Hematopoietic cell-specific knockout of the TFR2 gene causes microcytic erythrocytosis in mice (Kawabata et al. 2016). | Eukaryota |
Metazoa | TFR2 of Homo sapiens |
9.B.229.1.3 | PA domain protein of 891 aas and 1 TMS. | Eukaryota |
Fungi | PA domain protein of Beauveria bassiana (White muscardine disease fungus) (Tritirachium shiotae) |
9.B.229.1.4 | Putative Vacuolar protein sorting-associated protein 70 of 1042 aas and 1 TMS. | Eukaryota |
Fungi | V-S-aP of Glarea lozoyensis |
9.B.229.1.5 | Glutamate carboxypeptidase II of 727 aas and 1 N-terminal TMS. | Bacteria |
Bacteroidetes | Glutamate carboxypeptidase II of Rhodothermus marinus |
9.B.229.1.6 | Transferrin-like receptor protein, Tre1, of 783 aas and 1 (possibly 2 or 3) TMS(s). Tre1 can partially inhibit manganese uptake via Smf1 (TC# 2.A.55.1.1) by itself, but it requires Bsd2 (8.A.30.2.1) to induce Smf1 degradation (Stimpson et al. 2006). | Eukaryota |
Fungi | Tre1 of Saccharomyces cerevisiae |
9.B.229.1.7 | Tre2, a transferrin-like receptor protein of 809 aas and 1 (or mossibly more) TMS(s). May play a role in transport protein degredation via aubiquitin-dependent pathway involving multivesicular body sorting (Stimpson et al. 2006). | Eukaryota |
Fungi | Tre2 of Saccharomymes cerevisiae |