TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
9.B.229.1.1









The transferrin receptor, TfR or TFRC, of 760 aas and 1 TMS (Recalcati et al. 2017). Optimal conditions for Western blotting for this and other proteins requires that the sample not be boiled (Tsuji 2020).

Eukaryota
Metazoa
TfR of Homo sapiens
9.B.229.1.2









Transferrin receptor-2, TfR2 or TFR2 of 801 aas and 1 TMS.  TFR2, is predominantly expressed in hepatocytes and erythroid precursor cells. In the liver, TFR2 forms a complex with HFE, a hereditary hemochromatosis-associated protein, and acts as an iron sensor. In mice, hepatocyte-specific knockout of the TFR2 gene has been shown to cause systemic iron-overload with decreased expression of hepcidin, the central regulator of iron homeostasis. In erythroid cells, TFR2 forms a complex with the erythropoietin receptor and facilitates its trafficking to the cell membrane. Hematopoietic cell-specific knockout of the TFR2 gene causes microcytic erythrocytosis in mice (Kawabata et al. 2016).

Eukaryota
Metazoa
TFR2 of Homo sapiens
9.B.229.1.3









PA domain protein of 891 aas and 1 TMS. 

Eukaryota
Fungi
PA domain protein of Beauveria bassiana (White muscardine disease fungus) (Tritirachium shiotae)
9.B.229.1.4









Putative Vacuolar protein sorting-associated protein 70 of 1042 aas and 1 TMS.

Eukaryota
Fungi
V-S-aP of Glarea lozoyensis
9.B.229.1.5









Glutamate carboxypeptidase II of 727 aas and 1 N-terminal TMS.

Bacteria
Bacteroidetes
Glutamate carboxypeptidase II of Rhodothermus marinus
9.B.229.1.6









Transferrin-like receptor protein, Tre1, of 783 aas and 1 (possibly 2 or 3) TMS(s). Tre1 can partially inhibit manganese uptake via Smf1 (TC# 2.A.55.1.1) by itself, but it requires Bsd2 (8.A.30.2.1) to induce Smf1 degradation (Stimpson et al. 2006).

Eukaryota
Fungi
Tre1 of Saccharomyces cerevisiae
9.B.229.1.7









Tre2, a transferrin-like receptor protein of 809 aas and 1 (or mossibly more) TMS(s).  May play a role in transport protein degredation via aubiquitin-dependent pathway involving multivesicular body sorting (Stimpson et al. 2006).

Eukaryota
Fungi
Tre2 of Saccharomymes cerevisiae