TCDB is operated by the Saier Lab Bioinformatics Group

9.B.390.  The ER Tubular Junction (ER-TJ) Family 

The tubular network of the endoplasmic reticulum (ER) is formed by connecting ER tubules through three-way junctions. Two classes of the conserved ER membrane proteins, atlastins and lunapark, have been shown to reside at the three-way junctions so far and be involved in the generation and stabilization of the three-way junctions. Wisesa et al. 2019 reported TMCC3 (transmembrane and coiled-coil domain family 3), a member of the TEX28 family, as another ER membrane protein that resides at the three-way junctions in mammalian cells. When the TEX28 family members were transfected into U2OS cells, TMCC3 specifically localized at the three-way junctions in the peripheral ER. TMCC3 bound to atlastins through the C-terminal transmembrane domains of TMCC3. A TMCC3 mutant lacking the N-terminal coiled-coil domain abolished localization to the three-way junctions, suggesting that TMCC3 localized independently of binding to atlastins. TMCC3 knockdown caused a decrease in the number of three-way junctions and expansion of ER sheets, leading to a reduction of the tubular ER network. The TMCC3 knockdown phenotype was partially rescued by the overexpression of atlastin-2, suggesting that TMCC3 knockdown would decrease the activity of atlastins. Thus, TMCC3 localizes at the three-way junctions for the proper tubular ER network (Wisesa et al. 2019).

References associated with 9.B.390 family:

Bowling, S.A., J.D. Clarke, Y. Liu, D.F. Klessig, and X. Dong. (1997). The cpr5 mutant of Arabidopsis expresses both NPR1-dependent and NPR1-independent resistance. Plant Cell 9: 1573-1584. 9338960
Breuss, M.W., A. Nguyen, Q. Song, T. Nguyen, V. Stanley, K.N. James, D. Musaev, G. Chai, S.A. Wirth, P. Anzenberg, R.D. George, A. Johansen, S. Ali, M. Zia-Ur-Rehman, T. Sultan, M.S. Zaki, and J.G. Gleeson. (2018). Mutations in LNPK, Encoding the Endoplasmic Reticulum Junction Stabilizer Lunapark, Cause a Recessive Neurodevelopmental Syndrome. Am J Hum Genet 103: 296-304. 30032983
Chen, S., T. Desai, J.A. McNew, P. Gerard, P.J. Novick, and S. Ferro-Novick. (2015). Lunapark stabilizes nascent three-way junctions in the endoplasmic reticulum. Proc. Natl. Acad. Sci. USA 112: 418-423. 25548161
Faisal, M.B., T.S. Gechev, B. Mueller-Roeber, and P.P. Dijkwel. (2020). Putative alternative translation start site-encoding nucleotides of CPR5 regulate growth and resistance. BMC Plant Biol 20: 295. 32600419
Gao, L., Z. Ye, J.H. Liu, J.A. Yang, Y. Li, J.Y. Cai, Y.X. Wang, S.A. Tong, G. Deng, S. Zhang, and Q.X. Chen. (2022). TMCO1 expression promotes cell proliferation and induces epithelial-mesenchymal transformation in human gliomas. Med Oncol 39: 90. 35568751
Hu, J., Y. Shibata, P.P. Zhu, C. Voss, N. Rismanchi, W.A. Prinz, T.A. Rapoport, and C. Blackstone. (2009). A class of dynamin-like GTPases involved in the generation of the tubular ER network. Cell 138: 549-561. 19665976
Kirik, V., D. Bouyer, U. Schöbinger, N. Bechtold, M. Herzog, J.M. Bonneville, and M. Hülskamp. (2001). CPR5 is involved in cell proliferation and cell death control and encodes a novel transmembrane protein. Curr. Biol. 11: 1891-1895. 11728314
Moriya, K., K. Nagatoshi, Y. Noriyasu, T. Okamura, E. Takamitsu, T. Suzuki, and T. Utsumi. (2013). Protein N-myristoylation plays a critical role in the endoplasmic reticulum morphological change induced by overexpression of protein Lunapark, an integral membrane protein of the endoplasmic reticulum. PLoS One 8: e78235. 24223779
Perazza, D., F. Laporte, C. Balagué, F. Chevalier, S. Remo, M. Bourge, J. Larkin, M. Herzog, and G. Vachon. (2011). GeBP/GPL transcription factors regulate a subset of CPR5-dependent processes. Plant Physiol. 157: 1232-1242. 21875893
Shemesh, T., R.W. Klemm, F.B. Romano, S. Wang, J. Vaughan, X. Zhuang, H. Tukachinsky, M.M. Kozlov, and T.A. Rapoport. (2014). A model for the generation and interconversion of ER morphologies. Proc. Natl. Acad. Sci. USA 111: E5243-5251. 25404289
Wang, S., H. Tukachinsky, F.B. Romano, and T.A. Rapoport. (2016). Cooperation of the ER-shaping proteins atlastin, lunapark, and reticulons to generate a tubular membrane network. Elife 5:. 27619977
Wang, S., Y. Gu, S.G. Zebell, L.K. Anderson, W. Wang, R. Mohan, and X. Dong. (2014). A noncanonical role for the CKI-RB-E2F cell-cycle signaling pathway in plant effector-triggered immunity. Cell Host Microbe 16: 787-794. 25455564
Wisesa, S., Y. Yamamoto, and T. Sakisaka. (2019). TMCC3 localizes at the three-way junctions for the proper tubular network of the endoplasmic reticulum. Biochem. J. 476: 3241-3260. 31696206
Yang, Y. and D.J. Klionsky. (2020). A novel reticulophagy receptor, Epr1: a bridge between the phagophore protein Atg8 and ER transmembrane VAP proteins. Autophagy 1-2. [Epub: Ahead of Print] 33121335
Yoshida, S., M. Ito, I. Nishida, and A. Watanabe. (2002). Identification of a novel gene HYS1/CPR5 that has a repressive role in the induction of leaf senescence and pathogen-defence responses in Arabidopsis thaliana. Plant J. 29: 427-437. 11846876