The Endoplasmic Reticular (ER) three way tubular junctions, consisting of three known proteins, TMCC3, Atlastin-2 and Lunapark (Wisesa et al. 2019). See family description for details regarding TMCC3. Atlastin-2 is a GTPase, tethering membranes through formation of
trans-homooligomers and mediating homotypic fusion of ER membranes. It functions in ER tubular network
biogenesis (Hu et al. 2009, Wang et al. 2016). Lunapark (LNPK, LNP) is an
The ER-TJ complex of Homo sapiens,
TMCC3, 477 aas with 2 C-terminal TMSs, Q9ULS5.
Atlastin-2, 583 aas with two C-terminal TMSs, Q8NHH9; see family 1.G.5.
Lunapark, 428 aas with two N-terminal TMSs, Q9C0E8; see family 8.A.109.
Atlastin-3, ATL3, of 541 aas and 3 TMSs, 2 near the C-terminus, and possibly 1 near the N-terminus. It is a reticulophagy receptor (Yang and Klionsky 2020).
ATL3 of Homo sapiens