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TCIDNameDomainKingdom/PhylumProtein(s)
9.B.390.1.1









The Endoplasmic Reticular (ER) three way tubular junctions, consisting of three known proteins, TMCC3, Atlastin-2 and Lunapark (Wisesa et al. 2019). See family description for details regarding TMCC3. Atlastin-2 is a GTPase, tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of ER membranes. It functions in ER tubular network biogenesis (Hu et al. 2009, Wang et al. 2016). Lunapark (LNPK, LNP) is an
ER-shaping membrane protein that plays a role in determining ER morphology (Breuss et al. 2018). It is involved in the stabilization of nascent three-way ER tubular junctions within the ER network (Moriya et al. 2013, Shemesh et al. 2014, Chen et al. 2015, Wang et al. 2016). It may also play a role as a curvature-stabilizing protein within the three-way ER tubular junction network (Shemesh et al. 2014), and may also be involved in limb development as well as central nervous system development (Breuss et al. 2018).

Eukaryota
Metazoa
The ER-TJ complex of Homo sapiens,
consisting of:
TMCC3, 477 aas with 2 C-terminal TMSs, Q9ULS5.
Atlastin-2, 583 aas with two C-terminal TMSs, Q8NHH9; see family 1.G.5.
Lunapark, 428 aas with two N-terminal TMSs, Q9C0E8; see family 8.A.109.
9.B.390.1.2









Atlastin-3, ATL3, of 541 aas and 3 TMSs, 2 near the C-terminus, and possibly 1 near the N-terminus. It is a reticulophagy receptor (Yang and Klionsky 2020).

Eukaryota
Opisthokonta
ATL3 of Homo sapiens