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9.B.433. The Progesterone Receptor Membrane-associated Component 2 (PGRMC2) Family

PGRMC2 is required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan. It may serve as a universal non-classical progesterone receptor in the uterus. An intracellular heme chaperone is required for delivery of labile, or signaling heme to the nucleus. It plays a role in adipocyte function and systemic glucose homeostasis (Parker et al. 2017). It forms a complex with the dopamine transporter (TC# 2.A.22.1.3).

References associated with 9.B.433 family:

Parker, C.G., A. Galmozzi, Y. Wang, B.E. Correia, K. Sasaki, C.M. Joslyn, A.S. Kim, C.L. Cavallaro, R.M. Lawrence, S.R. Johnson, I. Narvaiza, E. Saez, and B.F. Cravatt. (2017). Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell 168: 527-541.e29. 28111073
Piniella, D., E. Martínez-Blanco, D. Bartolomé-Martín, A.B. Sanz-Martos, and F. Zafra. (2021). Identification by proximity labeling of novel lipidic and proteinaceous potential partners of the dopamine transporter. Cell Mol Life Sci. [Epub: Ahead of Print] 34709416