9.B.433. The Progesterone Receptor Membrane-associated Component (PGRMC) Family
PGRMC2 is required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan. It may serve as a universal non-classical progesterone receptor in the uterus. An intracellular heme chaperone is required for delivery of labile, or signaling heme to the nucleus. It plays a role in adipocyte function and systemic glucose homeostasis (Parker et al. 2017). It forms a complex with the dopamine transporter (TC# 2.A.22.1.3). Progesterone receptor membrane component 1 facilitates Ca2+ signal amplification between endosomes and the endoplasmic reticulum (Gunaratne et al. 2023).