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9.B.433. The Progesterone Receptor Membrane-associated Component (PGRMC) Family

PGRMC2 is required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan. It may serve as a universal non-classical progesterone receptor in the uterus. An intracellular heme chaperone is required for delivery of labile, or signaling heme to the nucleus. It plays a role in adipocyte function and systemic glucose homeostasis (Parker et al. 2017). It forms a complex with the dopamine transporter (TC# 2.A.22.1.3).  Progesterone receptor membrane component 1 facilitates Ca2+ signal amplification between endosomes and the endoplasmic reticulum (Gunaratne et al. 2023).

References associated with 9.B.433 family:

Gunaratne, G.S., S. Kumar, Y. Lin-Moshier, J.T. Slama, E. Brailiou, S. Patel, T.F. Walseth, and J.S. Marchant. (2023). Progesterone receptor membrane component 1 facilitates Ca signal amplification between endosomes and the endoplasmic reticulum. J. Biol. Chem. 105378. [Epub: Ahead of Print] 37866635
Parker, C.G., A. Galmozzi, Y. Wang, B.E. Correia, K. Sasaki, C.M. Joslyn, A.S. Kim, C.L. Cavallaro, R.M. Lawrence, S.R. Johnson, I. Narvaiza, E. Saez, and B.F. Cravatt. (2017). Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell 168: 527-541.e29. 28111073
Piel, R.B., 3rd, M.T. Shiferaw, A.A. Vashisht, J.R. Marcero, J.L. Praissman, J.D. Phillips, J.A. Wohlschlegel, and A.E. Medlock. (2016). A Novel Role for Progesterone Receptor Membrane Component 1 (PGRMC1): A Partner and Regulator of Ferrochelatase. Biochemistry 55: 5204-5217. 27599036
Piniella, D., E. Martínez-Blanco, D. Bartolomé-Martín, A.B. Sanz-Martos, and F. Zafra. (2021). Identification by proximity labeling of novel lipidic and proteinaceous potential partners of the dopamine transporter. Cell Mol Life Sci. [Epub: Ahead of Print] 34709416
Ryu, C.S., K. Klein, and U.M. Zanger. (2017). Membrane Associated Progesterone Receptors: Promiscuous Proteins with Pleiotropic Functions - Focus on Interactions with Cytochromes P450. Front Pharmacol 8: 159. 28396637