| TCID | Name | Domain | Kingdom/Phylum | Protein(s) |
|---|---|---|---|---|
|
9.B.433.1.1 | The progesterone receptor membrane component 2, PGRMC2 of 223 aas and1 TMS near the N-terminus. (see family description; it forms a complex with the dopamine transporter (TC#2.A.22.1.3) (Piniella et al. 2021). | Eukaryota |
Metazoa, Chordata | PGRMC2 of Homo sapiens |
|
9.B.433.1.2 | Membrane-associated progesterone-binding protein 4 isoform X2of 239 aas and 1 TM | Eukaryota |
Viridiplantae, Streptophyta | PGR of Spinacia oleracea |
|
9.B.433.1.3 | Uncharacterized protein of 239 aas and 1 TMS | Eukaryota |
UP of Tribonema minus | |
|
9.B.433.1.4 | Neuferricin-like protein of 540 aa | Eukaryota |
Rhodophyta | Neuferricin-like protein of Porphyridium purpureum |
|
9.B.433.1.5 | PGRMC1 (Membrane-associated progesterone receptor component 1) of 195 aas and one N-terminal TMS. It is a component of a progesterone-binding protein complex (Ryu et al. 2017). It has several reported cellular functions (heme homeostasis, interaction with CYPs), and is required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan. It is also an intracellular heme chaperone, regulating heme synthesis via interactions with FECH. It acts as a heme donor for at least some hemoproteins (Piel et al. 2016). It facilitates Ca2+ signal amplification between endosomes and the endoplasmic reticulum (Gunaratne et al. 2023). It is a TPC1 (TC # 1.A.1.11.25) interactor. | Eukaryota |
Metazoa, Chordata | PGRMC1 of Homo sapiens |
|
9.B.433.2.1 | Membrane steroid-binding protein 2 of 194 aas and 1 N-terminal TMS. | Eukaryota |
Metazoa, Arthropoda | Steroid binding protein of Drosophila eugracilis |