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9.B.435.  The Stimulator of Interferon Genes Protein (STING) Family 

STING is a facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta) (Ishikawa and Barber 2008Shang et al. 2019). Moreover, an alternatively spliced STING isoform localizes in the cytoplasmic membrane and directly senses extracellular cGAMP (Li et al. 2022) (see 2.A.48.1.1).

References associated with 9.B.435 family:

Ishikawa, H. and G.N. Barber. (2008). STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling. Nature 455: 674-678. 18724357
Li, X., Y. Zhu, X. Zhang, X. An, M. Weng, J. Shi, S. Wang, C. Liu, S. Luo, and T. Zheng. (2022). An alternatively spliced STING isoform localizes in the cytoplasmic membrane and directly senses extracellular cGAMP. J Clin Invest 132:. 34905508
Shang, G., C. Zhang, Z.J. Chen, X.C. Bai, and X. Zhang. (2019). Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP-AMP. Nature 567: 389-393. 30842659