TCDB is operated by the Saier Lab Bioinformatics Group

9.B.45. The Fungal Mating-type Pheromone Receptor (MAT-PR) Family 

The MAT-PR family consists of proteins with 7 TMSs and is considered to comprise Class D GPCR receptors (Shalaeva et al. 2015). The G protein-coupled receptors Ste2 and Ste3 bind α- and a-factor, respectively, in Saccharomyces cerevisiae. These receptors share a similar conformation, with seven transmembrane segments, three intracellular loops, a C-terminal tail, and three extracellular loops. However, the amino acid sequences of these two receptors bear little resemblance to each other, and the two ligands, α-factor and a-factor, have different sequences although both receptors activate the same G protein (Gastaldi et al. 2016).  These two subfamilies within the MMAT-PR Family are very distantly related, but both are distantly related to other GPCRs in TC Family 9.A.14.  They are therefore members of the TOG superfamily (Yee et al. 2013).

References associated with 9.B.45 family:

Di Segni, G., S. Gastaldi, M. Zamboni, and G.P. Tocchini-Valentini. (2011). Yeast pheromone receptor genes STE2 and STE3 are differently regulated at the transcription and polyadenylation level. Proc. Natl. Acad. Sci. USA 108: 17082-17086. 21969566
Gastaldi, S., M. Zamboni, G. Bolasco, G. Di Segni, and G.P. Tocchini-Valentini. (2016). Analysis of random PCR-originated mutants of the yeast Ste2 and Ste3 receptors. Microbiologyopen 5: 670-686. 27150158
Krystofova, S. and K.A. Borkovich. (2006). The predicted G-protein-coupled receptor GPR-1 is required for female sexual development in the multicellular fungus Neurospora crassa. Eukaryot. Cell. 5: 1503-1516. 16963633
Nakayama, N., A. Miyajima, and K. Arai. (1987). Common signal transduction system shared by STE2 and STE3 in haploid cells of Saccharomyces cerevisiae: autocrine cell-cycle arrest results from forced expression of STE2. EMBO. J. 6: 249-254. 15981334
Shalaeva, D.N., M.Y. Galperin, and A.Y. Mulkidjanian. (2015). Eukaryotic G protein-coupled receptors as descendants of prokaryotic sodium-translocating rhodopsins. Biol Direct 10: 63. 26472483
Turrà, D., M. El Ghalid, F. Rossi, and A. Di Pietro. (2015). Fungal pathogen uses sex pheromone receptor for chemotropic sensing of host plant signals. Nature 527: 521-524. 26503056
Vitale, S., A. Partida-Hanon, S. Serrano, &.#.1.9.3.;. Martínez-Del-Pozo, A. Di Pietro, D. Turrà, and M. Bruix. (2017). Structure-Activity Relationship of α Mating Pheromone from the Fungal Pathogen Fusarium oxysporum. J. Biol. Chem. 292: 3591-3602. 28100777
Yee, D.C., M.A. Shlykov, A. Västermark, V.S. Reddy, S. Arora, E.I. Sun, and M.H. Saier, Jr. (2013). The transporter-opsin-G protein-coupled receptor (TOG) superfamily. FEBS J. 280: 5780-5800. 23981446