TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


9.B.45.1.1
Mating-type pheromone α-receptor of 431 aas and 7 TMSs, STE2 (Nakayama et al. 1987).  The G protein-coupled receptors Ste2 and Ste3 bind α- and a-factor, respectively, in Saccharomyces cerevisiae. These receptors share a similar conformation, with seven transmembrane segments, three intracellular loops, a C-terminal tail, and three extracellular loops. However, the amino acid sequences of these two receptors bear little resemblance to each other, and the two ligands, α-factor and a-factor, have different sequences although both receptors activate the same G protein (Gastaldi et al. 2016).

Accession Number:D6VTK4
Protein Name:Pheromone alpha factor receptor
Length:431
Molecular Weight:47849.00
Species:Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [559292]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate NONE

Cross database links:

Structure:
1PJD   2K9P     

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence
1:	MSDAAPSLSN LFYDPTYNPG QSTINYTSIY GNGSTITFDE LQGLVNSTVT QAIMFGVRCG 
61:	AAALTLIVMW MTSRSRKTPI FIINQVSLFL IILHSALYFK YLLSNYSSVT YALTGFPQFI 
121:	SRGDVHVYGA TNIIQVLLVA SIETSLVFQI KVIFTGDNFK RIGLMLTSIS FTLGIATVTM 
181:	YFVSAVKGMI VTYNDVSATQ DKYFNASTIL LASSINFMSF VLVVKLILAI RSRRFLGLKQ 
241:	FDSFHILLIM SCQSLLVPSI IFILAYSLKP NQGTDVLTTV ATLLAVLSLP LSSMWATAAN 
301:	NASKTNTITS DFTTSTDRFY PGTLSSFQTD SINNDAKSSL RSRLYDLYPR RKETTSDKHS 
361:	ERTFVSETAD DIEKNQFYQL PTPTSSKNTR IGPFADASYK EGEVEPVDMY TPDTAADEEA 
421:	RKFWTEDNNN L