TCDB is operated by the Saier Lab Bioinformatics Group

9.B.87 The Selenoprotein P Receptor (SelP-Receptor) Family

Selenoprotein P (SelP) contains most of the selenium in blood plasma, and it is utilized by the kidney, brain and testis as a selenium source for selenoprotein synthesis. Apolipoprotein E receptor-2 (ApoER2) is required for SelP uptake by the testis, and deletion of ApoER2 reduces testis and brain, but not kidney, selenium levels. Neither the C-terminus selenocysteine-rich domain of SelP nor ApoER2 were required for SelP uptake by proximal tubules. SelP binds megalin, a lipoprotein receptor localized to the proximal tubule epithelium. Proximal tubules don't take up SelP in megalin null mice. Thus, kidney selenium homeostasis is mediated by a megalin-dependent SelP uptake pathway in the proximal tubule (Olson et al., 2008) that may use an endocytic mechanism (Thévenod, 2010).

Homologues of SelP receptors function in various capacities including regulation of ion transporters.  Therefore, this family could be assigned to subclass 8.A. For example, KRP4 (TC# 9.B.87.1.24) is involved in the formation of neuromuscular junctions, and in the regluation of acetyl choline receptors (Koppel et al. 2019). However, it is retained in family 9.B.87 because several family members appear to function in other capacities, an observation consistent with the tremendous variation in protein size and domain composition of the proteins assigned to this family.

References associated with 9.B.87 family:

and Thevenod F. (2010). Catch me if you can! Novel aspects of cadmium transport in mammalian cells. Biometals. 23(5):857-75. 20204475
Adachi, H. and M. Tsujimoto. (2002). FEEL-1, a novel scavenger receptor with in vitro bacteria-binding and angiogenesis-modulating activities. J. Biol. Chem. 277: 34264-34270. 12077138
Andersen, O.M., J. Reiche, V. Schmidt, M. Gotthardt, R. Spoelgen, J. Behlke, C.A. von Arnim, T. Breiderhoff, P. Jansen, X. Wu, K.R. Bales, R. Cappai, C.L. Masters, J. Gliemann, E.J. Mufson, B.T. Hyman, S.M. Paul, A. Nykjaer, and T.E. Willnow. (2005). sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein. Proc. Natl. Acad. Sci. USA 102: 13461-13466. 16174740
Bachmann, A., M. Schneider, E. Theilenberg, F. Grawe, and E. Knust. (2001). Drosophila Stardust is a partner of Crumbs in the control of epithelial cell polarity. Nature 414: 638-643. 11740560
Banerji, S., J. Ni, S.X. Wang, S. Clasper, J. Su, R. Tammi, M. Jones, and D.G. Jackson. (1999). LYVE-1, a new homologue of the CD44 glycoprotein, is a lymph-specific receptor for hyaluronan. J. Cell Biol. 144: 789-801. 10037799
Brecht, S., V.B. Carruthers, D.J. Ferguson, O.K. Giddings, G. Wang, U. Jakle, J.M. Harper, L.D. Sibley, and D. Soldati. (2001). The toxoplasma micronemal protein MIC4 is an adhesin composed of six conserved apple domains. J. Biol. Chem. 276: 4119-4127. 11053441
Brütsch, R., S.S. Liebler, J. Wüstehube, A. Bartol, S.E. Herberich, M.G. Adam, A. Telzerow, H.G. Augustin, and A. Fischer. (2010). Integrin cytoplasmic domain-associated protein-1 attenuates sprouting angiogenesis. Circ Res 107: 592-601. 20616313
Costa Mendonça-Natividade, F., C. Duque Lopes, R. Ricci-Azevedo, A. Sardinha-Silva, C. Figueiredo Pinzan, A.C. Paiva Alegre-Maller, L. L Nohara, A. B Carneiro, A. Panunto-Castelo, I. C Almeida, and M.C. Roque-Barreira. (2019). Receptor Heterodimerization and Co-Receptor Engagement in TLR2 Activation Induced by MIC1 and MIC4 from. Int J Mol Sci 20:. 31658592
daSilva, L.L., O. Foresti, and J. Denecke. (2006). Targeting of the plant vacuolar sorting receptor BP80 is dependent on multiple sorting signals in the cytosolic tail. Plant Cell 18: 1477-1497. 16714388
Eggert, S., C. Thomas, S. Kins, and G. Hermey. (2018). Trafficking in Alzheimer''s Disease: Modulation of APP Transport and Processing by the Transmembrane Proteins LRP1, SorLA, SorCS1c, Sortilin, and Calsyntenin. Mol Neurobiol 55: 5809-5829. 29079999
Gao, X.M., D.D. Zhang, C.C. Hou, C. Du, S.Y. Luo, and J.Q. Zhu. (2020). Developmental and mRNA transcript relative abundance pattern of vitellogenin receptors, LR8-/Lrp13, during ovarian development in the large yellow croaker (Larimichthys crocea). Anim Reprod Sci 213: 106271. 31987324
Hogg, D.W., M. Husić, D. Wosnick, T. Dodsworth, A.L. D''Aquila, and D.A. Lovejoy. (2019). Activity of the Carboxy-Terminal Peptide Region of the Teneurins and Its Role in Function and Behavior in Mammals. Front Neurosci 13: 581. 31417336
Hung, C.H., X. Qiao, P.T. Lee, and M.G. Lee. (2004). Clathrin-dependent targeting of receptors to the flagellar pocket of procyclic-form Trypanosoma brucei. Eukaryot. Cell. 3: 1004-1014. 15302833
Iorio, J., C. Duranti, T. Lottini, E. Lastraioli, G. Bagni, A. Becchetti, and A. Arcangeli. (2020). K11.1 Potassium Channel and the Na/H Antiporter NHE1 Modulate Adhesion-Dependent Intracellular pH in Colorectal Cancer Cells. Front Pharmacol 11: 848. 32587517
Jobst-Schwan, T., K.X. Knaup, R. Nielsen, T. Hackenbeck, M. Buettner-Herold, P. Lechler, S. Kroening, M. Goppelt-Struebe, U. Schloetzer-Schrehardt, B.G. Fürnrohr, R.E. Voll, K. Amann, K.U. Eckardt, E.I. Christensen, and M.S. Wiesener. (2013). Renal uptake of the antiapoptotic protein survivin is mediated by megalin at the apical membrane of the proximal tubule. Am. J. Physiol. Renal Physiol 305: F734-744. 23825075
Kinoshita, A., T. Shah, M.M. Tangredi, D.K. Strickland, and B.T. Hyman. (2003). The intracellular domain of the low density lipoprotein receptor-related protein modulates transactivation mediated by amyloid precursor protein and Fe65. J. Biol. Chem. 278: 41182-41188. 12888553
Klar, J., J. Schuster, T.N. Khan, M. Jameel, K. Mäbert, L. Forsberg, S.A. Baig, S.M. Baig, and N. Dahl. (2015). Whole exome sequencing identifies LRP1 as a pathogenic gene in autosomal recessive keratosis pilaris atrophicans. J Med Genet 52: 599-606. 26142438
Klassen, R.B., K. Crenshaw, R. Kozyraki, P.J. Verroust, L. Tio, S. Atrian, P.L. Allen, and T.G. Hammond. (2004). Megalin mediates renal uptake of heavy metal metallothionein complexes. Am. J. Physiol. Renal Physiol 287: F393-403. 15126248
Kole, M.J., J. Qian, M.P. Waase, T.L. Klassen, T.T. Chen, G.J. Augustine, and J.L. Noebels. (2015). Selective Loss of Presynaptic Potassium Channel Clusters at the Cerebellar Basket Cell Terminal Pinceau in Adam11 Mutants Reveals Their Role in Ephaptic Control of Purkinje Cell Firing. J. Neurosci. 35: 11433-11444. 26269648
Koppel, N., M.B. Friese, H.L. Cardasis, T.A. Neubert, and S.J. Burden. (2019). Vezatin is required for the maturation of the neuromuscular synapse. Mol. Biol. Cell 30: 2571-2583. 31411944
Kounnas, M.Z., R.E. Morris, M.R. Thompson, D.J. FitzGerald, D.K. Strickland, and C.B. Saelinger. (1992). The alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein binds and internalizes Pseudomonas exotoxin A. J. Biol. Chem. 267: 12420-12423. 1618748
Kzhyshkowska, J., S. Mamidi, A. Gratchev, E. Kremmer, C. Schmuttermaier, L. Krusell, G. Haus, J. Utikal, K. Schledzewski, J. Scholtze, and S. Goerdt. (2006). Novel stabilin-1 interacting chitinase-like protein (SI-CLP) is up-regulated in alternatively activated macrophages and secreted via lysosomal pathway. Blood 107: 3221-3228. 16357325
Leupin, O., E. Piters, C. Halleux, S. Hu, I. Kramer, F. Morvan, T. Bouwmeester, M. Schirle, M. Bueno-Lozano, F.J. Fuentes, P.H. Itin, E. Boudin, F. de Freitas, K. Jennes, B. Brannetti, N. Charara, H. Ebersbach, S. Geisse, C.X. Lu, A. Bauer, W. Van Hul, and M. Kneissel. (2011). Bone overgrowth-associated mutations in the LRP4 gene impair sclerostin facilitator function. J. Biol. Chem. 286: 19489-19500. 21471202
May, P. and J. Herz. (2003). LDL receptor-related proteins in neurodevelopment. Traffic 4: 291-301. 12713657
May, P., Y.K. Reddy, and J. Herz. (2002). Proteolytic processing of low density lipoprotein receptor-related protein mediates regulated release of its intracellular domain. J. Biol. Chem. 277: 18736-18743. 11907044
Michishita, M., T. Ikeda, T. Nakashiba, M. Ogawa, K. Tashiro, T. Honjo, K. Doi, S. Itohara, and S. Endo. (2004). Expression of Btcl2, a novel member of Btcl gene family, during development of the central nervous system. Brain Res Dev Brain Res 153: 135-142. 15464227
Nishida-Fukuda, H., R. Araki, M. Shudou, H. Okazaki, Y. Tomono, H. Nakayama, S. Fukuda, T. Sakaue, Y. Shirakata, K. Sayama, K. Hashimoto, M. Detmar, S. Higashiyama, and S. Hirakawa. (2016). Ectodomain Shedding of Lymphatic Vessel Endothelial Hyaluronan Receptor 1 (LYVE-1) Is Induced by Vascular Endothelial Growth Factor A (VEGF-A). J. Biol. Chem. 291: 10490-10500. 26966180
Nishimune, H. and K. Shigemoto. (2018). Practical Anatomy of the Neuromuscular Junction in Health and Disease. Neurol Clin 36: 231-240. 29655446
Olson, G.E., V.P. Winfrey, K.E. Hill, and R.F. Burk. (2008). Megalin mediates selenoprotein P uptake by kidney proximal tubule epithelial cells. J. Biol. Chem. 283(11): 6854-6860. 18174160
Paul, N.R., G. Jacquemet, and P.T. Caswell. (2015). Endocytic Trafficking of Integrins in Cell Migration. Curr. Biol. 25: R1092-1105. 26583903
Polacheck, W.J., M.L. Kutys, J. Yang, J. Eyckmans, Y. Wu, H. Vasavada, K.K. Hirschi, and C.S. Chen. (2017). A non-canonical Notch complex regulates adherens junctions and vascular barrier function. Nature 552: 258-262. 29160307
Potla, R., M. Hirano-Kobayashi, H. Wu, H. Chen, A. Mammoto, B.D. Matthews, and D.E. Ingber. (2020). Molecular mapping of transmembrane mechanotransduction through the β1 integrin-CD98hc-TRPV4 axis. J Cell Sci. [Epub: Ahead of Print] 32989042
Prevo, R., S. Banerji, J. Ni, and D.G. Jackson. (2004). Rapid plasma membrane-endosomal trafficking of the lymph node sinus and high endothelial venule scavenger receptor/homing receptor stabilin-1 (FEEL-1/CLEVER-1). J. Biol. Chem. 279: 52580-52592. 15345716
Pupovac, A. and R. Sluyter. (2016). Roles of extracellular nucleotides and P2 receptors in ectodomain shedding. Cell Mol Life Sci. [Epub: Ahead of Print] 27180276
Reiss, M., N. Viebig, S. Brecht, M.N. Fourmaux, M. Soete, M. Di Cristina, J.F. Dubremetz, and D. Soldati. (2001). Identification and characterization of an escorter for two secretory adhesins in Toxoplasma gondii. J. Cell Biol. 152: 563-578. 11157983
Romeo, R., K. Glotzbach, A. Scheller, and A. Faissner. (2020). Deletion of LRP1 From Astrocytes Modifies Network Activity in an Model of the Tripartite Synapse. Front Cell Neurosci 14: 567253. 33519378
Saint-Jean, B., E. Seveno-Carpentier, C. Alcon, J.M. Neuhaus, and N. Paris. (2010). The cytosolic tail dipeptide Ile-Met of the pea receptor BP80 is required for recycling from the prevacuole and for endocytosis. Plant Cell 22: 2825-2837. 20807880
Saouros, S., B. Edwards-Jones, M. Reiss, K. Sawmynaden, E. Cota, P. Simpson, T.J. Dowse, U. Jäkle, S. Ramboarina, T. Shivarattan, S. Matthews, and D. Soldati-Favre. (2005). A novel galectin-like domain from Toxoplasma gondii micronemal protein 1 assists the folding, assembly, and transport of a cell adhesion complex. J. Biol. Chem. 280: 38583-38591. 16166092
Sawmynaden, K., S. Saouros, N. Friedrich, J. Marchant, P. Simpson, B. Bleijlevens, M.J. Blackman, D. Soldati-Favre, and S. Matthews. (2008). Structural insights into microneme protein assembly reveal a new mode of EGF domain recognition. EMBO Rep 9: 1149-1155. 18818666
Silva, J.P., V.G. Lelianova, Y.S. Ermolyuk, N. Vysokov, P.G. Hitchen, O. Berninghausen, M.A. Rahman, A. Zangrandi, S. Fidalgo, A.G. Tonevitsky, A. Dell, K.E. Volynski, and Y.A. Ushkaryov. (2011). Latrophilin 1 and its endogenous ligand Lasso/teneurin-2 form a high-affinity transsynaptic receptor pair with signaling capabilities. Proc. Natl. Acad. Sci. USA 108: 12113-12118. 21724987
Sundararajan, T., A.M. Manzardo, and M.G. Butler. (2018). Functional analysis of schizophrenia genes using GeneAnalytics program and integrated databases. Gene 641: 25-34. 29032150
Tepass, U., C. Theres, and E. Knust. (1990). crumbs encodes an EGF-like protein expressed on apical membranes of Drosophila epithelial cells and required for organization of epithelia. Cell 61: 787-799. 2344615
Tufail, M. and M. Takeda. (2009). Insect vitellogenin/lipophorin receptors: molecular structures, role in oogenesis, and regulatory mechanisms. J Insect Physiol 55: 87-103. 19071131
Urata, Y., W. Saiki, Y. Tsukamoto, H. Sago, H. Hibi, T. Okajima, and H. Takeuchi. (2020). Xylosyl Extension of -Glucose Glycans on the Extracellular Domain of NOTCH1 and NOTCH2 Regulates Notch Cell Surface Trafficking. Cells 9:. 32423029
Yi, S., S. Wang, Q. Zhao, C. Yao, Y. Gu, J. Liu, X. Gu, and S. Li. (2016). miR-sc3, a novel miRNA, promoted Schwann cell proliferation and migration by targeting Astn1. Cell Transplant. [Epub: Ahead of Print] 26786955