9.B.87.4.1
Tumor necrosis factor receptor, Ngfr, or Tumor necrosis factor receptor superfamily member 16, Tnfrsf16, or death receptor, p75(NTR), of 427 aas and 3 TMSs, one N-terminal, and two centrally located between residues 220 and 280. It is a low affinity receptor which can bind to NGF, BDNF, NTF3, and NTF4, and it forms a heterodimeric receptor with SORCS2 that binds the precursor forms of NGF, BDNF and NTF3 with high affinity. It has much lower affinity for mature NGF and BDNF (Glerup et al. 2014). It plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and it thereby contributes to the regulation of insulin-dependent glucose uptake (Lin et al. 2015). Inactive variants of p75(NTR) reduce Alzheimer's neuropathology by interfering with amyloid precursor protein (APP) internalization (Yi et al. 2021).