9.C.19. The PolyPhenol Uptake (PPU) Family
Polyphenol-rich lentil hull are a potential source of nutrients for animals. Among the bioaccessible polyphenols, catechin glucoside, kaempferol tetraglucoside, procyanidin dimers and dihydroxybenzoic acid-O-dipentoside were most efficiently transported across the caco-2 membrane, and responsible for promoting intestinal integrity as a result of enhanced expression of tight junction proteins. When ingested by rats, lentil hull polyphenols underwent extensive I and II phase metabolic reactions in vivo, including hydroxylation, methylation, glucuronidation and sulfation. Thus, lentil hull polyphenols are bioaccessible and bioavailable, and lentil hulls as a by-product can be a valuable ingredient for future functional foods (Guo et al. 2023). The transport proteins have not been identified.