1.A.102 The Influenza A viroporin PB1-F2 (PB1-F2) Family

The PB1-F2 protein of 90 aas, and possibly a weakly hydrophobic C-terminal TMS, exhibits viroporin activity, transporting monovalent cations and Ca2+ (Hyser and Estes 2015). 


 

References:

Chanturiya, A.N., G. BasaƱez, U. Schubert, P. Henklein, J.W. Yewdell, and J. Zimmerberg. (2004). PB1-F2, an influenza A virus-encoded proapoptotic mitochondrial protein, creates variably sized pores in planar lipid membranes. J. Virol. 78: 6304-6312.

Hyser, J.M. and M.K. Estes. (2015). Pathophysiological Consequences of Calcium-Conducting Viroporins. Annu Rev Virol 2: 473-496.

Examples:

TC#NameOrganismal TypeExample
1.A.102.1.1

The PB1-F2 protein of 90 aas, and possibly a weakly hydrophobic C-terminal TMS, exhibits viroporin activity, transporting monovalent cations and Ca2+ (Hyser and Estes 2015).

PB1-F2 of Influenza virus A

 
1.A.102.1.2

Influenza A virus PB1-F2 protein of 57 aas

PB1-F2 of INfluenza A virus

 
1.A.102.1.3

PB1-F2 protein of 57 aas and 0 TMSs

PB1-F2 of Influenza A virus (A/chicken/Dongguan)

 
1.A.102.1.4

PB1-F2 viroporin of 90 aas. It is an influenza A virus-encoded proapoptotic mitochondrial protein that creates variably sized pores in planar lipid membranes (Chanturiya et al. 2004).

PB1F2 of influenza A virus