1.A.115.  The Pore-forming NADPH-dependent 1-Acyldihydroxyacetone Phosphate Reductase (Ayr1) Family

The short-chain dehydrogenase-related protein Ayr1 forms an NADPH-regulated channel in lipid bilayers and in the outer mitochondrial membrane (Krüger et al. 2017). It conducts ions across the outer membrane (Checchetto and Szabo 2018).


 

References:

Checchetto, V. and I. Szabo. (2018). Novel Channels of the Outer Membrane of Mitochondria: Recent Discoveries Change Our View. Bioessays 40: e1700232.

Krüger, V., T. Becker, L. Becker, M. Montilla-Martinez, L. Ellenrieder, F.N. Vögtle, H.E. Meyer, M.T. Ryan, N. Wiedemann, B. Warscheid, N. Pfanner, R. Wagner, and C. Meisinger. (2017). Identification of new channels by systematic analysis of the mitochondrial outer membrane. J. Cell Biol. 216: 3485-3495.

Examples:

TC#NameOrganismal TypeExample
1.A.115.1.1

The outer mitochondrial membrane pore-forming NADPH-dependent 1-acyldihydroxyacetone phosphate reductase, Ayr1. Unlike most outer membrane porins, Ayr1 consists of α-helicies rather than β-strands (Krüger et al. 2017).

Ayr1 of Saccharomyces cerevisiae

 
1.A.115.1.2

NAD-binding protein of 261 aas and 1 TM

NAD BP of Euryarchaeota archaeon

 
1.A.115.1.3

SDR family of NAD(P)-dependent oxidoreductases of 287 aas and 0 TM

SDR family protein of Allonocardiopsis opalescens

 
1.A.115.1.4

Uncharacterized protein of 188 aas and 3 putative TMSs.

UP of Botrytis elliptica

 
1.A.115.1.5

SDR family oxidoreductase of 250 aas and 1 TM

SDR family protein of Pseudomonas abietaniphila