1.A.115. The Pore-forming NADPH-dependent 1-Acyldihydroxyacetone Phosphate Reductase (Ayr1) Family
The short-chain dehydrogenase-related protein Ayr1 forms an NADPH-regulated channel in lipid bilayers and in the outer mitochondrial membrane (Krüger et al. 2017). It conducts ions across the outer membrane (Checchetto and Szabo 2018).
The outer mitochondrial membrane pore-forming NADPH-dependent 1-acyldihydroxyacetone phosphate reductase, Ayr1. Unlike most outer membrane porins, Ayr1 consists of α-helicies rather than β-strands (Krüger et al. 2017).
Ayr1 of Saccharomyces cerevisiae
NAD-binding protein of 261 aas and 1 TM
NAD BP of Euryarchaeota archaeon
SDR family of NAD(P)-dependent oxidoreductases of 287 aas and 0 TM
SDR family protein of Allonocardiopsis opalescens
Uncharacterized protein of 188 aas and 3 putative TMSs.
UP of Botrytis elliptica
SDR family oxidoreductase of 250 aas and 1 TM
SDR family protein of Pseudomonas abietaniphila