1.A.115.  The Pore-forming NADPH-dependent 1-Acyldihydroxyacetone Phosphate Reductase (Ayr1) Family

The short-chain dehydrogenase-related protein Ayr1 forms an NADPH-regulated channel in lipid bilayers and in the outer mitochondrial membrane (Krüger et al. 2017). It conducts ions across the outer membrane (Checchetto and Szabo 2018).



Checchetto, V. and I. Szabo. (2018). Novel Channels of the Outer Membrane of Mitochondria: Recent Discoveries Change Our View. Bioessays 40: e1700232.

Krüger, V., T. Becker, L. Becker, M. Montilla-Martinez, L. Ellenrieder, F.N. Vögtle, H.E. Meyer, M.T. Ryan, N. Wiedemann, B. Warscheid, N. Pfanner, R. Wagner, and C. Meisinger. (2017). Identification of new channels by systematic analysis of the mitochondrial outer membrane. J. Cell Biol. 216: 3485-3495.


TC#NameOrganismal TypeExample

The outer mitochondrial membrane pore-forming NADPH-dependent 1-acyldihydroxyacetone phosphate reductase, Ayr1. Unlike most outer membrane porins, Ayr1 consists of α-helicies rather than β-strands (Krüger et al. 2017).

Ayr1 of Saccharomyces cerevisiae


NAD-binding protein of 261 aas and 1 TM

NAD BP of Euryarchaeota archaeon


SDR family of NAD(P)-dependent oxidoreductases of 287 aas and 0 TM

SDR family protein of Allonocardiopsis opalescens


Uncharacterized protein of 188 aas and 3 putative TMSs.

UP of Botrytis elliptica


SDR family oxidoreductase of 250 aas and 1 TM

SDR family protein of Pseudomonas abietaniphila