1.A.142.  The C20.5L Viroporin (C20.5L-VP) Family 

This family has been examined, first, showing that its characterized member is a  small transmembrane protein of 49 aas and 1 N-terminal TMS (residues 6 - 26). Second, it has been shown to have ion channel activity (Basu et al. 2023). Third, its 3-D transmembrane structure has been predicted using alpha-fold.


 

References:

Basu, K., M. Krugliak, and I.T. Arkin. (2023). Viroporins of Mpox Virus. Int J Mol Sci 24:.

Examples:

TC#NameOrganismal TypeExample
1.A.142.1.1

Monkeypox virus (Mpox virus; Mpkv) viroporin of 49 aas and 1 N-terminal TMS.  It forms an oligomeric transmembrane pore that transports ions (Basu et al. 2023).

Viroporin of Monkeypox virus

 
1.A.142.1.2

IMV protein (putatie viroporin) of 49 aas and 1 N-terminal TMS.

IMV protein of NY_014 poxvirus

 
1.A.142.1.3

IMV protein of 49 aas and  1 N-terminal TMS.

IMV protein of Raccoonpox virus