1.A.152.  The Putative Ion Channel-Receptor (PICR) Family 

These proteins are large and have about 7 TMSs in a 2 + 2 + 2 + 1 TMS arrangement.  They may be members of the Odoran Receptor Channel Superfamily.



This family belongs to the Odorant Receptor Channel.

 

References:

Himmel, N.J., D. Moi, and R. Benton. (2023). Remote homolog detection places insect chemoreceptors in a cryptic protein superfamily spanning the tree of life. Curr. Biol. 33: 5023-5033.e4.

Examples:

TC#NameOrganismal TypeExample
1.A.152.1.1

The Phtf putative ion channel-receptor protein of 880 aas and about 7 TMSs in a2 or 3 + 2 + 2 + 1 TMS arrangement.

Phtf of Drosophila melanogaster

 
1.A.152.1.2

Putative Phtf1 ion channel protein of 762 aas and possibly 7 TMSs in a 2 + 2 + 2 + 1 TMS arrangement.

PHTF of Homo sapiens

 
1.A.152.1.3

Phtf2 of 785 aas and 7  TMSs in a 2 or 2 + 2 + 2 + 1 TMS arrangement (Himmel et al. 2023).

Phtf2 of Homo sapiens

 
1.A.152.1.4

PhtF of 752 aas and 7 TMSs in a 2 + 2 + 2 + 1 TMS arrangement.

PhtF of Gallus gallus