1.A.92 The Reovirus Viroporin VP10 (RVP10) Family
Scylla serrata reovirus (SsRV) is a pathogen that can severely
damage mud crab (Scylla serrata) aquaculture. Protein p35 with 2 TMSs, also called VP10, is encoded by the S10 gene. SsRV p35 can induce membrane permeability changes
when expressed in Escherichia coli. Expressed in bacterial
cells, it exists as monomers under reducing conditions but forms
homodimers and homotrimers under non-reducing conditions. p35 therefore has the properties of a viroporin. It may resemble NS3-like proteins (TC#9.B.66).
Scylla serrata reovirus of 323 aas and 2 N-terminal TMSs, p35 or VP10, encoded by the S10 gene. This proposed viroporin seems to transport ions in a channel-type mechanism (Zhang et al. 2015). This putative viroporin interacts with host proteins (Yuan et al. 2017).
p35 of Scylla serrata reovirus
Uncharaterized protein of 323 aas and 2 or 3 N-terminal TMSs.
UP of Eriocheir sinensis reovirus
VP10 of 340 aas and 2 or 3 N-terminal TMSs. This protein is 73% identical to 1.A.92.1.2.
VP10 of Eriocheir sinensis reovirus