1.D.272.  The Supramolecular Zn²⁺ Channel (SZnC) Family   

Artificial ion channels have potential for various applications, including molecular communication, bio-sensing, and constructing artificial cells. Srimayee et al. 2025 developed a molecular communication system that transports ions across the lipid bilayers via the formation of supramolecular ion channels.  It harnesses chemical reactions to overcome the challenges of executing signal-processing functions at the molecular level. The potent ionophore self-assembles into nanochannels within the lipid bilayers and selectively transports Zn²⁺ ions. The movement of Zn²⁺ ions through these supramolecular ion channels enables the in situ generation of a water-soluble catalytic system with tyrosine. This catalytic system promotes esterase-like activity, generating fluorescent reporters from non-fluorescent ester-based compounds within the intravesicular environment. Furthermore, this process indicates the formation of a three-input AND logic gate in the fluorescence mode, allowing the monitoring of the chemical-to-optical signal amplification process akin to biological counterparts. Developing these molecular communication systems to replicate the complexity of natural cellular processes opens up exciting opportunities for designing advanced biomimetic tools and exploring the fundamental principles underlying cellular communication (Srimayee et al. 2025).

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