1.D,327. The Cascaded Hydrated Acid Cation Channel (CHACC) Family

A unimolecular artificial cation channel based on cascaded hydrated acids has been developed (Xin et al. 2024). The cation channel possessing cascaded hydrated acid groups was constructed using pillar[5]arene integrated with dual cyclodextrins. The secondary side of cyclodextrin substituted by 24 -CO₂H groups presents high coordination sites, which helps hydrated cations to quickly dehydrate and accelerates efficient cation transport (Rb⁺ > Cs⁺ > K⁺ > Na⁺ > Li⁺). Benefitted by the protonation and deprotonation of -CO₂H groups, ion permeation activity of the channel molecules under acidic condition (pH = 6.0) is 2.8 times higher than that under alkaline conditions (pH = 8.0), exhibiting pH-modulated property and promising potential in building intelligent artificial ion channels with customized features.

References:

Xin, P., H. Yuan, L. Zhang, Q. Zhu, X. Ning, Y. Song, Y. Shu, and Y. Sun. (2024). A unimolecular artificial cation channel based on cascaded hydrated acid groups. J Mater Chem B 12: 10835-10838.