1.D.333. The Artificial Ion-transporting Signal Transduction System (AISTS) Family

An artificial signal transduction system has been developed that is able to control the influx of environmental ions by triggering the activation of synthetic transmembrane channels immobilized in giant membrane vesicles (GMVs) (Yang et al. 2021). A membrane protein-like stimulator from one GMV community (GMV_B) stimulates a receptor on another GMV community (GMV_A) to release ssDNA messengers, resulting in the activation of synthetic transmembrane channels to enable the influx of ions.

References:

Yang, Q., Z. Guo, H. Liu, R. Peng, L. Xu, C. Bi, Y. He, Q. Liu, and W. Tan. (2021). A Cascade Signaling Network between Artificial Cells Switching Activity of Synthetic Transmembrane Channels. J. Am. Chem. Soc. 143: 232-240.