1.D.44 The Synthetic Ion Channel with Redox-active Ferrocene (ICRF) Family. 

The synthesis, cation binding and transmembrane conductive properties of a novel synthetic ion channel compound containing a redox-active ferrocene unit have been described by Tsikolia et al. 2009. Fluorescence spectroscopy was used to demonstrate that the channel supports multiple ion coordination and association constants for 1:1 and 1:2 (channel:cation) coordination for both Na+ and K+. Experiments using a black lipid membrane preparation revealed that this compound functioned effectively as an ion channel for both ions, and 23Na+ NMR spectroscopy  revealed a Na+ flux, at least 5 times higher than ion transport rates by monensin. Furthermore, oxidation of the redox-active centre (Fe2+ to Fe3+) effectively inhibited ion transport.



Tsikolia, M., A.C. Hall, C. Suarez, Z.O. Nylander, S.M. Wardlaw, M.E. Gibson, K.L. Valentine, L.N. Onyewadume, D.A. Ahove, M. Woodbury, M.M. Mongare, C.D. Hall, Z. Wang, B. Draghici, and A.R. Katritzky. (2009). Synthesis and characterization of a redox-active ion channel supporting cation flux in lipid bilayers. Org Biomol Chem 7: 3862-3870.