1.E.26 The Holin LLH (Holin LLH) Family
The Holin LLH family is found in Firmicutes and phage of Firmicutes as well as other bacteria. Members are fairly large ((100 - 160 aas) and have an N-terminal transmembrane segment.
References:
Holin (105 aas)
Firmicutes
Holin of Clostridium phytofermentans
Putative holin of 186 aas
Firmicutes
Putative holin of Paenibacillus polymyxa
Uncharacterized protein of 172 aas
Firmicutes
UP of Lactobacillus brevis
Putative holin of 109 aas and 1 TMS
Chloroflexi
Putative holin of Nitrolancea hollandica
Putative holin of 113 aas and 1 TMS
Firmicutes
Putative holin of Paenibacillus polymyxa
SE-1 phage holin of 123 aas and 1-3 TMSs (Yuan et al. 2016).
Firmicutes
Holiin of SE-1 phage infecting Erysipelothrix rhusiopathiae
Phage holin of the LL0H family (110 aas)
Firmicutes
Holin of Streptococcus pneumoniae
Putative holin of 1112 aas and 1 TMS
Firmicutes
Putative holin of Caldicellulosiruptor owensensis
Putative holin of 109 aas and 2 TMSs
Thermotogae
Putative holin of Marinitoga piezophila
Holin of S. mutans phage M102 (van der Ploeg 2007).
Firmicute viruses
Holin of phage M102
Putative holin of 109 aas and 1 TMS.
Firmicutes
Putative holin of Caldicellulosiruptor hydrothermalis
Holin_LLH superfamily member
Firmicutes
holin of Desulfotomaculum gibsoniae
Putative holin of 112 aas, Gp072
Firmicute virus
Gp072 of Lactococcus phage KSY1
Uncharacterized protein of 107 aas
Tenericutes
UP of Acholeplasma laidlawii
Putative holin of 140 aas and 1 or 2 TMSs
Thermus
Putative holin of Meiothermus ruber
Putative holin of 140 aas and 1 TMS
Thermus
Putative holin of Thermus sp. RL
Holin of Thermus phage P23-77 of 140 aas and 1 TMS
Thermus
Holin of Thermus phage P23-77
Holin of Lactobacillus phage LF1
Firmicute viruses
Holin of Lactobacillus phage LF1
Holin P163 (Gindreau and Lonvaud-Funel 1999).
Firmicute viruses
Holin P163 of Leuconostoc phage 10MC
Putative holin of 117 aas
Firmicute virus
Putative holin of Lactobacillus phage JCL1032
Uncharacterized protein of 140 aa
Firmicutes
UP of Lactobacillus acidophilus
Holin, Hyb50 of 254 aas. This holin causes lysis by itself, but with the lytic enzyme, Lyb50, lysis occurs more rapidly (Wang et al. 2008). Smaller amounts of Lyb50 can reach the periplasm without the holin (Guo et al. 2015).
Lactobacillus virus
Holin of Lactobacillus phage phiPYB5
Holin of the LL-H family (105 aas)
Firmicutes
Holin LL-H of Peptoniphilus harei
Uncharacterized protein of 126 aas and 1 TMS
Firmicutes
UP of Clostridium acetobutylicum
Putative holin of 153 aas and 1 TM
Firmicutes
Holin of Lactococcus lactis
Putative holin of 118 aas and 1 TMS
Thermus
Putative holin of Thermus phage P74-26
Uncharacterized protein of 145 aas and 1 TMS
Firmicutes
UP of Clostridium kluyveri
Putative holin of 166 aas
Firmicutes
Putative porin of Desulfosporosinus meridiei
Uncharaccterized protein of 177 aas
Firmicutes
UP of Thermoanaerobacterium saccharolyticum
Uncharacterized protein of 96 aas
Firmicutes
UP of Clostridium acidurici
Putative holin of 162 aas and 1 or 2 TMSs
Fusobacteria
Putative holin of Fusobacterium varium
Putative holin of 162 aas and 1 or 2 TMSs
Fusobacteria
Putative holin of Fusobacterium ulcerans
Putative holin of 167 aas and 1 or 2 TMSs
Fusobacteria
Putative holin of Sebaldella termitidis
Putative holin of 134 aas and 1 TMS
Firmicutes
Putative holin of Faecalibacterium prausnitzii
Uncharacterized protein of 172 aas
Firmicutes
UP of Clostridium pasteurianum
Holin of 114 aas
Firmicutes
Holin of Lactobacillus johnsonii