1.E.33 The 2 or 3 TMS Putative Holin (2/3 Holin) Family The 2/3 Holin family consists of many proteobacterial proteins ranging in size from about 70 aas to 120 aas. They have 2 or 3 predicted TMSs. Although some are annotated as phage proteins or holins, none appears to be functionally characterized.
Examples:
TC#	Name	Organismal Type	Example
1.E.33.1.1	Putative holin of 95 aas and 3 TMSs	β-Proteobacteria	Putative holin of Sideroxydans lithotrophicus

1.E.33.1.2	DUF4063 family protein	γ-Proteobacteria	DUF4063 family protein of Arsenophonus nasoniae

1.E.33.1.3	Holin of 109 aas and 2 or 3 TMSs	δ-Proteobacteria	*Holin of Desulfovibrio* sp. A2**

1.E.33.1.4	Hypothetical protein of 119 aas and 2 or 3 TMSs	δ-Proteobacteria	Hypothetical protein of Biophila wadsworthia

1.E.33.1.5	Putative holin of 92 aas and 3 TMSs	γ-Proteobacteria	Putative holin of Cardiobacterium hominis

1.E.33.1.6	Putative holin of 87 aas and 3 TMSs	β-Proteobacteria	Putative holin of Sideroxydans lithotrophicus

1.E.33.1.7	Putative holin of 107 aas and 2 TMSs	γ-Proteobacteria	*Putative holin of Rhodanobacter* sp.**

Examples:
TC#	Name	Organismal Type	Example