*1.E.49 The Putative Treponema* 4 TMS Holin (Tre4Hol) Family** The Tre4Hol Family consists of several proteins from Treponema species. They have sizes of 100 - 110 aas and have 4 TMSs. A fragment has been sequenced from Treponema phage Phi td1 (D2ECI8) and was designated a putative holin.
Examples:
TC#	Name	Organismal Type	Example
1.E.49.1.1	Hypothetical protein of 101 aas and 4 TMSs.	Spirochaetes	HP of Treponema denticola

1.E.49.1.2	Hypothetical protein of 108 aas and 4 TMSs.	Spirochaetes	HP of Treponema phagedenis

1.E.49.1.3	Putative holin of 105 aas and 4 TMSs in a 2 + 2 TMS arrangement.	Spirochaetes	Putative holin of Treponema denticola

1.E.49.1.4	Putative phage holin of 41 aas and 1 TMS	Spirochaete phage	Putative holin of phage phi td1

1.E.49.1.5	Putative holin of 105 aas and 4 TMSs		Holiin of Treponema socranskii