1.E.72. The Archaeal/Bacterial 4 TMS Putative Holin (AB4Holin) Family The AB-4Holin family includes many small proteins, all of which have 4 TMSs per polypeptide chain. Homology with SMR-like proteins has been considered but not established, while sequence similarities with holins in Holin III Superfamily are considerable. Additional bacterial homologues may be found in other TC Families containing 4 TMS members. Other homologs may have 3 TMSs because these sequences are not complete. TC family 9.B.106 members have 3 or 4 TMSs with C-terminal hydrophylic domains, and the N-terminal TMSs may be homologous to those of members of Holin family 1.E.72.
This family belongs to the Holin IV Superfamily .
Examples:
TC#	Name	Organismal Type	Example
1.E.72.1.1	Archaeal 4 TMS protein of 171 aas		4 TMS protein of Natrialba magadii (Natronobacterium magadii)

1.E.72.1.2	SPW repeat protein of 157 aas and 4 TMSs.		UP of Natrialba taiwanensis

1.E.72.1.3	Uncharacterized protein of 184 aas and 4 TMSs.		UP of Saccharomonospora marina

1.E.72.1.4	SPW repeat protein of 110 aas and 3 or 4 TMSs		SPW repeat protein of Natronococcus jeotgali

1.E.72.1.5	Uncharacterized protein of 121 aas and 4 TMSs		UP of Nitrolancea hollandica

1.E.72.1.6	SPW repeat protein of 119 aas and 4 TMSs, Gp25	Proteobacteria	SPW repeat protein, Gp25, of Rhizobium mesoamericanum

1.E.72.1.7	Uncharacterized protein of 133 aas and 4 TMSs.		UP of Kutzneria albida