2.A.101 The Malonate Uptake (MatC) Family (Formerly UIT1)

The UIT1 family is a constituent of the IT superfamily (Lolkema and Slotboom, 2003; Prakash et al., 2003; Rabus et al., 1999). It is the st308/DctB family of Lolkema and Slotboom (2003). It consists of proteins from Gram-negative and Gram-positive bacteria (e.g., Xanthomonas, Rhizobium and Streptomyces species). The proteins are of about 450 aas with 12-14 putative TMSs. Closest functionally-characterized homologues are in the DASS (TC #2.A.47) family. One member of this family is a putative malonate transporter (An and Kim, 1998).

MatC is a part of the IT superfamily.

This family belongs to the IT Superfamily.



An, J.H. and Y.S. Kim. (1998). A gene cluster encoding malonyl-CoA decarboxylase (MatA), malonyl-CoA synthetase (MatB) and a putative dicarboxylate carrier protein (MatC) in Rhizobium trifolii--cloning, sequencing, and expression of the enzymes in Escherichia coli. Eur J Biochem 257: 395-402.

Lolkema, J.S. and D.J. Slotboom. (2003). Classification of 29 families of secondary transport proteins into a single structural class using hydropathy profile analysis. J. Mol. Biol. 327: 901-909.

Prakash, S., G. Cooper, S. Singhi, and M.H. Saier, Jr. (2003). The ion transporter superfamily. Biochim. Biophys. Acta. 1618: 79-92.

Rabus, R., D.L. Jack, D.J. Kelly, and M.H. Saier, Jr. (1999). TRAP transporters: an ancient family of extracytoplasmic solute-receptor-dependent secondary active transporters. Microbiology 145(Pt12): 3431-3445.


TC#NameOrganismal TypeExample

Putative transporter, FkbF


FkbF of Streptomyces hygroscopicus var. ascomyceticus (Q9KIE8)


The putative malonate uptake porter, MatC (An and Kim, 1998) (distantly related to members of the DASS family (2.A.47))


MatC of Rhizobium leguminosarum bv trifolii (C6B3K0)