2.A.120 The Putative Amino Acid Permease (PAAP) Family

The PAAP family consists of many proteins all of a uniform topology with a 5 + 5 TMS repeat in a 2 + 3 + 2 + 3 arrangement. These proteins show similarity to members of the LIVCS family (TC# 2.A.26) in the APC Superfamily (Vastermark et al. 2014). There does not seem to be a single member that has been functionally characterized as of 8/2014. However, a large majority of the genes encoding these transporters occur in operons or gene clusters encoding enzymes of amino acid metabolism. These incude proteases, sporulation proteins, amino acid aminotransferases, amino acid and oxo acid oxidoreductases, and amino acid tRNA synthetases.


This family belongs to the APC Superfamily.
 

References:

Vastermark, A., S. Wollwage, M.E. Houle, R. Rio, and M.H. Saier, Jr. (2014). Expansion of the APC superfamily of secondary carriers. Proteins 82: 2797-2811.
Examples:

TC#NameOrganismal TypeExample
2.A.120.1.1

Putative permease of 349 aas

Firmicutes

PP of Staphylococcus epidermidis

 
2.A.120.1.10

Putative amino acid transporter, YkvI

Firmicutes

YkvI of Bacillus subtilis

 
2.A.120.1.11

Putative amino acid uptake porter of 700 aas, BrkK, with a C-terminal Lactamase B domain.

Firmicutes

BrkK of Eubacterium brachy

 
2.A.120.1.12

Putative alanine:sodium symporter

Firmicutes

Putative transporter of Mogibacterium sp.

 
2.A.120.1.13

Uncharacterized protein

Crenarchaota

UP of Caldivirga maquilingensis

 
2.A.120.1.2

Putative permease of 372 aas

Firmicutes

PP of Coprococcus catus

 
2.A.120.1.3

Putative permease of 496 aas

Firmicutes

PP of Clostridium botulinum

 
2.A.120.1.4

Putative permease of 378 aas

Prtoteobacteria

PP of Sphingopyxis alaskensis

 
2.A.120.1.5

Putative permease of 378 aas

Archaea

PP of Pyrococcus horikoshii

 
2.A.120.1.6

Putative permease of 326 aas

Firmicutes

PP of Caldicellulosiruptor kristjanssonii

 
2.A.120.1.7

Putative permease of 358 aas

Firmicutes

PP of Desulfotomaculum acetoxidans

 
2.A.120.1.8

Putative permease of 355 aas

Firmicutes

PP of Staphylococcus carnosus

 
2.A.120.1.9

Putative amino acid transporter, YyaD, which possibly plays a role in sporulation.

Firmicutes

YyaD of Bacillus subtilis

 
Examples:

TC#NameOrganismal TypeExample