2.A.120 The Putative Amino Acid Permease (PAAP) Family
The PAAP family consists of many proteins all of a uniform topology with a 5 + 5 TMS repeat in a 2 + 3 + 2 + 3 arrangement. These proteins show similarity to members of the LIVCS family (TC# 2.A.26) in the APC Superfamily (Vastermark et al. 2014). There does not seem to be a single member that has been functionally characterized as of 8/2014. However, a large majority of the genes encoding these transporters occur in operons or gene clusters encoding enzymes of amino acid metabolism. These incude proteases, sporulation proteins, amino acid aminotransferases, amino acid and oxo acid oxidoreductases, and amino acid tRNA synthetases.
References:
Putative permease of 349 aas
Firmicutes
PP of Staphylococcus epidermidis
Putative amino acid transporter, YkvI
Firmicutes
YkvI of Bacillus subtilis
Putative amino acid uptake porter of 700 aas, BrkK, with a C-terminal Lactamase B domain.
Firmicutes
BrkK of Eubacterium brachy
Putative alanine:sodium symporter
Firmicutes
Putative transporter of Mogibacterium sp.
Uncharacterized protein
Crenarchaota
UP of Caldivirga maquilingensis
Putative permease of 372 aas
Firmicutes
PP of Coprococcus catus
Putative permease of 496 aas
Firmicutes
PP of Clostridium botulinum
Putative permease of 378 aas
Prtoteobacteria
PP of Sphingopyxis alaskensis
Putative permease of 378 aas
Archaea
PP of Pyrococcus horikoshii
Putative permease of 326 aas
Firmicutes
PP of Caldicellulosiruptor kristjanssonii
Putative permease of 358 aas
Firmicutes
PP of Desulfotomaculum acetoxidans
Putative permease of 355 aas
Firmicutes
PP of Staphylococcus carnosus
Putative amino acid transporter, YyaD, which possibly plays a role in sporulation.
Firmicutes
YyaD of Bacillus subtilis