2.B.123. The Bisindole-based Anion Antiporter (BbAA) Family

Salunke et al. 2024 developed a novel bisindole-based transporter capable of efficient transmembrane anion antiport. This system induced cytotoxicity in MCF-7 breast cancer cells via (1) chloride ion homeostasis disruption, (2) the associated ROS generation, (3) mitochondrial membrane depolarization, and (4) lysosomal deacidification.

References:

Salunke, S.B., S.N. Save, N.J. Roy, R. Naorem, S. Sharma, and P. Talukdar. (2024). Bisindole-based small molecules as transmembrane anion transporters and potential anticancer agents. Org Biomol Chem 22: 4987-4992.