2.B.136. The Synthetic Anion Receptor Ion Transporter (SARIT) Family

The construction of synthetic transmembrane transporters for physiologically important chloride ions has been achieved (Rather et al. 2024). The synthesis of two new double walled trifluorophenyl/phthalimide extended calix[4]pyrrole (C4P) receptors (3 and 7) were reported. ¹H-NMR titration and HRMS studies confirmed the 1 : 1 binding stoichiometry of the chloride ion with these receptors in the solution phase. Regarding ion transport of 3b and 7, when studied in the HPTS-based vesicular system, 3b showed better activity with an EC₅₀ value of 0.39 μM. The detailed ion transport studies on 3b have revealed that ion transport occurs through the Cl^-/NO₃^- antiport mode, and therefore must function as a carrier rather than a channel (Rather et al. 2024).

References:

Rather, I.A., M. Ahmad, P. Talukdar, and R. Ali. (2024). Probing and evaluating transmembrane chloride ion transport in double walled trifluorophenyl/phthalimide extended calix[4]pyrrole-based supramolecular receptors. J Mater Chem B 12: 5950-5956.