2.B.28 The Oligo(aryl-triazole) Anion Transporter (OAT-AT) Family A series of oligo(aryl-triazole)s (compounds 1-8) have been synthesized, and they served as transmembrane anion transporters by only CH-Cl^- interactions. By changing the lipophilicity and anion affinity of the compounds, efficient anion transport with remarkable Cl^- vs. HCO₃^- selectivity has been achieved (Chen et al. 2016). It is not entirely clear if a carrier or channel mechanism is operative.
This family belongs to the Triazole-containing Channel/Carrier Superfamily.
References:
Chen, S., S. Zhang, C. Bao, C. Wang, Q. Lin, and L. Zhu. (2016). Oligo(aryl-triazole)s CHCl^- interactions guide chloride efficient and selective transmembrane transport. Chem Commun (Camb) 52: 13132-13135.