2.B.70. The Zinc Oxide (ZnO) Nanoparticle (NP) (ZnO-NP) Drug Carrier Family Zinc oxide (ZnO) nanoparticles (NPs) provide a promising platform for use in biomedical research, especially given their anticancer and antimicrobial activities. These activities are associated with the ability of ZnO NPs to generate reactive oxygen species (ROS) and induce apoptosis. In addition, ZnO NPs have been successfully exploited as drug carriers for loading and transporting drugs to target sites, thereby reducing unwanted toxicity and off-target effects, and resulting in amplified synergistic effects. The synthesis and biomedical applications of ZnO NPs have been reviewed (Mishra et al. 2017). The toxic effects of different types of zinc oxide nanoparticles on algae, plants, invertebrates, vertebrates and microorganisms have been reviewed (Hou et al. 2018). Pathways of cellular uptake, subcellular distribution and excretion of NPs have also been reviewed (Liu and Tang 2020). Moreover, electrochemical-based biosesors on different Zinc Oxide nanostructures has been discussed (Napi et al. 2019). Metal (zinc, iron, titanium, copper, etc.) oxide nanoparticles are widely used in therapeutic applications as drugs, nanocarriers, and diagnostic tools, and macrophages can recognize and engulf nanoparticles (Dukhinova et al. 2019; Bathi et al. 2021). Plants and the rhizosphere are affected by ZnO NPs (Liu et al. 2022). ZnO NPs are promising nanofungicides for effective control of rice blast disease (Ghamari et al. 2022).
References:
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