2.B.77. The Rigid-Axle-based Molecular Rotaxane Channel (RA-RC) Family

Inspired by the design criteria of heteroditopic receptors for ion-pair binding, Pang et al. 2023 described a new strategy to construct a rotaxane transporter for K⁺/Cl^- co-transport. The use of a rigid axle improves the transport activity with an EC₅₀ value of 0.58 μM, presenting a significant step toward developing rotaxane artificial channels.

References:

Pang, S., X. Sun, Z. Yan, C. Wang, K. Ye, S. Ma, L. Zhu, and C. Bao. (2023). A rigid-axle-based molecular rotaxane channel facilitates K/Cl co-transport across a lipid membrane. Chem Commun (Camb). [Epub: Ahead of Print]