2.B.78.  The Synthetic Isophthalamide Anion Transporter (SIAT) Family 

Several derivatives of Isophthalamide have been synthetically developed as anion carriers.  They can function as antiporters of anions such as F-/Cl-, OH-/Cl- and F-/NO3- antiporters as well as anion uniporters.  Several papers have been published describing the properties of these derivatives with respect to transport.  For references see: (1) Cataldo et al. 2023 and (2) Davis et al. 2020. Structures of some of these compounds (1 - 6) are shown below.

 


 

References:

Cataldo, A., M. Chvojka, G. Park, V. Šindelář, F.P. Gabbaï, S.J. Butler, and H. Valkenier. (2023). Transmembrane transport of fluoride studied by time-resolved emission spectroscopy. Chem Commun (Camb) 59: 4185-4188.
Davis, J.T., P.A. Gale, and R. Quesada. (2020). Advances in anion transport and supramolecular medicinal chemistry. Chem Soc Rev. [Epub: Ahead of Print]