8.A.101.  The TMEM263 (TMEM263) Family 

The transmembrane protein 263 (TMEM 263) is an interaction partners of both native Slick (TC# 1.A.1.3.6) and Slack (TC# 1.A.1.3.4) channels which also form hetero-oligomeric channels (Rizzi et al. 2015).



Rizzi, S., C. Schwarzer, L. Kremser, H.H. Lindner, and H.G. Knaus. (2015). Identification of potential novel interaction partners of the sodium-activated potassium channels Slick and Slack in mouse brain. Biochem Biophys Rep 4: 291-298.


TC#NameOrganismal TypeExample

TMEM263 of 116 aas and 2 TMSs.  Forms a complex with the Slick (1.A.1.3.6) and Slack (1.A.1.3.4) channels which can form a heteromeric complex with TMEM263 and other proteins which are presumed to regulate these channels (Rizzi et al. 2015).

TMEM263 of Homo sapiens


Uncharacterized protein of 128 aas.

UP of Mizuhopecten yessoensis (Yesso scallop)


Uncharacterized protein of 105 aas

UP of Biomphalaria glabrata


Uncharacterized protein of 83 aas

UP of Exaiptasia pallida