| 8.A.103. The Secretory Carrier-Associated Membrane Protein (SCAMP) Family
SCAMPs are in a family of highly related products of distinct genes, but SCAMP1, SCAMP2 and SCAMP3 largely colocalize at vesicle fusion sites (Singleton et al. 1997). The mammalian (Na+,K+/H+ exchanger, NHE7, resides chiefly in the
trans-Golgi network (TGN) and post-Golgi vesicles where it contributes to organellar pH homeostasis (Lin et al. 2005). SCAMPs 1-4 are ubiquitously expressed and are major components of the
eukaryotic cell surface recycling system. Castle and Castle 2005 found that different SCAMPs function along distinct pathways and behave like mobile trafficking machineries. In plants, SCAMPs influence accumulation of secondary cell wall components,
including polysaccharides and phenolic compounds, in the woody tissues
of tree stems (Obudulu et al. 2018).
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| References: |
Castle, A. and D. Castle. (2005). Ubiquitously expressed secretory carrier membrane proteins (SCAMPs) 1-4 mark different pathways and exhibit limited constitutive trafficking to and from the cell surface. J Cell Sci 118: 3769-3780.
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Fernández-Chacón, R. and T.C. Südhof. (2000). Novel SCAMPs lacking NPF repeats: ubiquitous and synaptic vesicle-specific forms implicate SCAMPs in multiple membrane-trafficking functions. J. Neurosci. 20: 7941-7950.
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Fjorback, A.W., H.K. Müller, J. Haase, M.K. Raarup, and O. Wiborg. (2011). Modulation of the dopamine transporter by interaction with Secretory Carrier Membrane Protein 2. Biochem. Biophys. Res. Commun. 406: 165-170.
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Lin, P.J., W.P. Williams, Y. Luu, R.S. Molday, J. Orlowski, and M. Numata. (2005). Secretory carrier membrane proteins interact and regulate trafficking of the organellar (Na+,K+)/H+ exchanger NHE7. J Cell Sci 118: 1885-1897.
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Liu, L., H. Liao, A. Castle, J. Zhang, J. Casanova, G. Szabo, and D. Castle. (2005). SCAMP2 interacts with Arf6 and phospholipase D1 and links their function to exocytotic fusion pore formation in PC12 cells. Mol. Biol. Cell 16: 4463-4472.
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Liu, L., Z. Guo, Q. Tieu, A. Castle, and D. Castle. (2002). Role of secretory carrier membrane protein SCAMP2 in granule exocytosis. Mol. Biol. Cell 13: 4266-4278.
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Müller, H.K., O. Wiborg, and J. Haase. (2006). Subcellular redistribution of the serotonin transporter by secretory carrier membrane protein 2. J. Biol. Chem. 281: 28901-28909.
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Obudulu, O., N. Mähler, T. Skotare, J. Bygdell, I.N. Abreu, M. Ahnlund, M. Latha Gandla, A. Petterle, T. Moritz, T.R. Hvidsten, L.J. Jönsson, G. Wingsle, J. Trygg, and H. Tuominen. (2018). A multi-omics approach reveals function of Secretory Carrier-Associated Membrane Proteins in wood formation of Populus trees. BMC Genomics 19: 11.
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Singleton, D.R., T.T. Wu, and J.D. Castle. (1997). Three mammalian SCAMPs (secretory carrier membrane proteins) are highly related products of distinct genes having similar subcellular distributions. J Cell Sci 110(Pt17): 2099-2107.
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| Examples: |
| TC# | Name | Organismal Type | Example |
| 8.A.103.1.1 | SCAMP1 of 338 aas and 4 TMSs | | SCAMP1 of Homo sapiens |
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| 8.A.103.1.10 | SCAMP4 of 225 aas and 4 TMSs. | | SCMAP4 of Strigomonas culicis |
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| 8.A.103.1.12 | SCAMP of 193 aas and 4 TMSs | | SCAMP of Rhizophagus irregularis |
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| 8.A.103.1.13 | SCAMP of 184 aas and 4 TMSs. | | SCAMP of Paramicrosporidium saccamoebae |
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| 8.A.103.1.14 | SCAMP of 359 aas and 4 TMSs | | SCAMP of Leishmania panamensis |
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| 8.A.103.1.15 | SCAMP of 216 aas and 4 TMSs. | | SCAMP of Tetrahymena thermophila |
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| 8.A.103.1.2 | SCAMP2 of 329 aas and 4 TMSs. Required for vesicle fusion pore formation (Liu et al. 2005). Interacts directly with the serotonin transporter and promotes its localization to the plasma membrane (Müller et al. 2006). It also interacts directly with the dopamine transporter, DAT, to regluate its activity and localization (Fjorback et al. 2011). | | SCAMP2 of Homo sapiens |
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| 8.A.103.1.3 | SCAMP3 of 347 aas and 4 TMSs. | | SCAMP3 of Homo sapiens |
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| 8.A.103.1.4 | SCAMP4 of 229 aas and 4 TMSs | | SCAMP4 of Homo sapiens |
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| 8.A.103.1.5 | SCAMP5 of 235 aas and 4 TMSs. | | SCAMP5 of Homo sapiens |
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| 8.A.103.1.6 | SCAMP1 of 282 aas and 4 TMSs (Fernández-Chacón and Südhof 2000). | | SCAMP1 of Arabidopsis thaliana (Mouse-ear cress) |
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| 8.A.103.1.7 | SCAMP of 343 aas and 4 TMSs (Fernández-Chacón and Südhof 2000). | | SCAMP of Drosophila melanogaster (Fruit fly) |
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| 8.A.103.1.8 | SCAMP1, Scm-1, of 335 aas and 4 TMSs. | | Scm-1 of Caenorhabditis elegans |
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| 8.A.103.1.9 | SCAMP of 226 aas and 4 TMSs | | SCAMP of Trypanosoma cruzi |
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