8.A.129. The Blood Vessel Epicardial Substance (BVES) Family BVES os a cell adhesion molecule involved in the establishment and/or maintenance of cell integrity, and the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells (Osler et al. 2005). It also plays a role in VAMP3-mediated vesicular transport and recycling of different receptor molecules through its interaction with VAMP3. It induces primordial adhesive contact and aggregation of epithelial cells in a Ca²⁺-independent manner and is involved in striated muscle regeneration and repair, and in the regulation of cell spreading. It plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding and, probably, by increasing cell surface expression of the potassium channel KCNK2 while enhancing current density (Schindler et al. 2016).
References:
Osler, M.E., M.S. Chang, and D.M. Bader. (2005). Bves modulates epithelial integrity through an interaction at the tight junction. J Cell Sci 118: 4667-4678.
Schindler, R.F., C. Scotton, J. Zhang, C. Passarelli, B. Ortiz-Bonnin, S. Simrick, T. Schwerte, K.L. Poon, M. Fang, S. Rinné, A. Froese, V.O. Nikolaev, C. Grunert, T. Müller, G. Tasca, P. Sarathchandra, F. Drago, B. Dallapiccola, C. Rapezzi, E. Arbustini, F.R. Di Raimo, M. Neri, R. Selvatici, F. Gualandi, F. Fattori, A. Pietrangelo, W. Li, H. Jiang, X. Xu, E. Bertini, N. Decher, J. Wang, T. Brand, and A. Ferlini. (2016). POPDC1(S201F) causes muscular dystrophy and arrhythmia by affecting protein trafficking. J Clin Invest 126: 239-253.
Yau, K.W. (1994). Cyclic nucleotide-gated channels: an expanding new family of ion channels. Proc. Natl. Acad. Sci. USA 91: 3481-3483.
Examples:
TC#	Name	Organismal Type	Example
8.A.129.1.1	BVES of 260 aas and 3 TMSs; It regulates junctions and potassium channels (see family description).		BVES of Homo sapiens

8.A.129.1.2	Popeye domain-containing protein 3 of 305 aas and 3 TMSs near the N-terminus.		*Popeye protein of Tinamus guttatus* (white-throated tinamou)**

8.A.129.1.3	Uncharacterized cyclic nucleotide-binding domain-containing protein of 218 aas and 2 or 3 TMSs.		UP of Solimonas fluminis

8.A.129.1.4	Uncharacterized cyclic nucleotide-binding domain-containing protein of 295 aas and 4 N-terminal TMSs (Yau 1994).		UP of Planctomycetes bacterium HG15A2

8.A.129.1.5	Uncharacterized blood vessel epicardial substance-like protein (BVESL) of 355 aas and 3 or more TMSs.		BVES of Hondaea fermentalgiana

8.A.129.1.6	Uncharacterized protein of 1099 aas and 2 or more TMSs.		UP of Eimeria mitis

8.A.129.1.7	Uncharacterized protein of 674 aas and 3 central TMSs		UP of Chara braunii