8.A.132. The Interferon/Interleukin Receptor (IIR) Family Interferon and interleukin receptors are thought to have evolved from a common ancestor in the early jawed vertebrates (Secombes and Zou 2017). The Supressor of Lurcher 1, SOL1 (TC# 8.A.132.1.1), of 557 aas and 2 TMSs, one N-terminal and one C-terminal, is a homolog of these receptors. SOL1 proteins regulate ionotropic glutamate receptor desensitization (Walker et al. 2006). SOL1 is an accessory protein requlred for glutamate-gated currents by Glr-1 (Zheng et al. 2004). This protein has an internal duplication and belongs to the FN3 superfamily.
References:
Bogdanov, V.Y., V. Balasubramanian, J. Hathcock, O. Vele, M. Lieb, and Y. Nemerson. (2003). Alternatively spliced human tissue factor: a circulating, soluble, thrombogenic protein. Nat. Med. 9: 458-462.
Cai, K., X. Zhang, and X.C. Bai. (2022). Cryo-electron Microscopic Analysis of Single-Pass Transmembrane Receptors. Chem Rev. [Epub: Ahead of Print]
Secombes, C.J. and J. Zou. (2017). Evolution of Interferons and Interferon Receptors. Front Immunol 8: 209.
Walker, C.S., M.M. Francis, P.J. Brockie, D.M. Madsen, Y. Zheng, and A.V. Maricq. (2006). Conserved SOL-1 proteins regulate ionotropic glutamate receptor desensitization. Proc. Natl. Acad. Sci. USA 103: 10787-10792.
Zanin, N., C. Viaris de Lesegno, C. Lamaze, and C.M. Blouin. (2020). Interferon Receptor Trafficking and Signaling: Journey to the Cross Roads. Front Immunol 11: 615603.
Zheng, Y., J.E. Mellem, P.J. Brockie, D.M. Madsen, and A.V. Maricq. (2004). SOL-1 is a CUB-domain protein required for GLR-1 glutamate receptor function in C. elegans. Nature 427: 451-457.
Examples:
TC#	Name	Organismal Type	Example
8.A.132.1.1	The Supressor of Lurcher 1, SOL1, or interferon alpha/beta receptor 1, IFNAR1, of 557 aas and 2 TMSs, one N-terminal and one C-terminal. SOL1 proteins regulate ionotropic glutamate receptor desensitization (Walker et al. 2006). SOL1 is an accessory protein requlred for glutamate-gated currents by Glr-1 (Zheng et al. 2004). This protein has an internal duplication and belongs to the FN3 superfamily. Its trafficking and signaling have been reported (Zanin et al. 2020).		SOL1 of Caenorhabditis elegans

8.A.132.1.10	Interferon gamma receptor 1 of 437 aas and 1 TMS.		*Interferon receptor of Amazona aestiva* (blue-fronted amazon)**

8.A.132.1.11	Uncharacterized protein of 571 aas and 1 N-terminal TMS		*UP of Maylandia zebra* (zebra mbuna)**

8.A.132.1.12	Interferon lambda receptor 1 isoform X1 of 504 aas and 1 TMS.		*Interferon receptor of Manis javanica* (Malayan pangolin)**

8.A.132.1.13	Interleukin-10 receptor, subunits alpha/beta. The alpha subunit has 578 aas with 2 TMSs, one N-terminal and the other at ~ residue 245 and the beta subunit is of 325 aas, with 2 TMSs, one N-terminal and the other at ~ residue 230. A cryoEM structure is available (Cai et al. 2022).		Interleukin-10 of Homo sapiens

8.A.132.1.2	Uncharacterized protein of 897 aas and 2 TMSs, N-terminal and in the middle of the protein.		UP of Branchiostoma belcheri

8.A.132.1.3	Uncharacterized protein of 621 aas and 2 TMSs, one N-terminal and one in the middle of the protein.		UP of Fundulus heteroclitus

8.A.132.1.4	Interleukin-22 receptor subunit alpha-1-like protein of 253 aas and 1 N-terminal TMS. This protein, in contrast to the homologues with TC#s 8.Al47.2.1 - 2.3, has a single repeat unit rather than a duplicated structure.		Interlleukin-22 receptor of Xenopus laevis

8.A.132.1.5	Uncharacterized proteinof 871 aas and 3 apparent TMSs, 2 N-terminal and one towards the C-terminus of the protein.		UP of Ciona intestinalis

8.A.132.1.6	Interferon gamma receptor 2 of 349 aas and 1 TMS		*Interferon receptor of Heterocephalus glaber* (naked mole-rat)**

8.A.132.1.7	Interleukin-20 receptor subunit beta isoform X1 of 403 aas and 6 TMSs in a 3 + 3 TMS arrangement.		*Interleukin receptor of Ursus maritimus* (polar bear)**

8.A.132.1.8	Interleukin-22 receptor subunit alpha-1 of 581 aas and 1 TMS		*Interleukin receptor of Panthera tigris* altaica (Amur tiger)**

8.A.132.1.9	Interferon lambda receptor 1-like isoform X2 of 556 aas and 2 TMSs, one N-terminal and one central.		Interferon receptor of Oncorhynchus mykiss (rainbow trout)

Examples:
TC#	Name	Organismal Type	Example
8.A.132.2.1	Tissue factor F3 of 295 aas and 2 TMSs, N- and C-terminal. It initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade (Bogdanov et al. 2003).		TF3 of Homo sapiens