8.A.138. The Constitutive Expresser of Pathogenesis-related 5 (CPR5) Family

Arabidopsis CONSTITUTIVE EXPRESSER of PATHOGENESIS-RELATED 5 (CPR5) has 564 aas and 5 C-terminal TMSs in a 1 + 4 TMS arrangement. It plays a role in gating as part of the nuclear pore complex (NPC), and mutations in CPR5 cause multiple defects, including aberrant trichomes, reduced ploidy levels, reduced growth and enhanced resistance to bacterial and fungal pathogens (Faisal et al. 2020). It regulates negatively the senescence and chlorotic lesions induced by biotic (e.g. pathogens) and abiotic (e.g. sugars, darkness) agents, probably by controlling programmed cell death (PDC) (Yoshida et al. 2002). It is a negative regulator of plant programmed cell death (PCD) and effector-triggered immunity (ETI) (Wang et al. 2014). It is a nucleoporin that when mutant, activates autoimmune responses that partially mimic effector-triggered immunity (ETI) (Xu et al. 2021).


 

References:

Faisal, M.B., T.S. Gechev, B. Mueller-Roeber, and P.P. Dijkwel. (2020). Putative alternative translation start site-encoding nucleotides of CPR5 regulate growth and resistance. BMC Plant Biol 20: 295.

Wang, S., Y. Gu, S.G. Zebell, L.K. Anderson, W. Wang, R. Mohan, and X. Dong. (2014). A noncanonical role for the CKI-RB-E2F cell-cycle signaling pathway in plant effector-triggered immunity. Cell Host Microbe 16: 787-794.

Xu, F., M. Jia, X. Li, Y. Tang, K. Jiang, J. Bao, and Y. Gu. (2021). Exportin-4 coordinates nuclear shuttling of TOPLESS family transcription corepressors to regulate plant immunity. Plant Cell. [Epub: Ahead of Print]

Yoshida, S., M. Ito, I. Nishida, and A. Watanabe. (2002). Identification of a novel gene HYS1/CPR5 that has a repressive role in the induction of leaf senescence and pathogen-defence responses in Arabidopsis thaliana. Plant J. 29: 427-437.

Examples:

TC#NameOrganismal TypeExample
8.A.138.1.1

Arabidopsis CONSTITUTIVE EXPRESSER of PATHOGENESIS-RELATED 5 (CPR5) has 564 aas and 5 C-terminal TMSs in a 1 + 4 TMS arrangement. It plays a role in gating as part of the nuclear pore complex (NPC), and mutations in CPR5 cause multiple defects, including aberrant trichomes, reduced ploidy levels, reduced growth and enhanced resistance to bacterial and fungal pathogens (Faisal et al. 2020). It regulates negatively the senescence and chlorotic lesions induced by biotic (e.g. pathogens) and abiotic (e.g. sugars, darkness) agents, probably by controlling programmed cell death (pcd) (Yoshida et al. 2002). It is a negative regulator of plant programmed cell death (PCD) and effector-triggered immunity (ETI) (Wang et al. 2014).

CPR5 of Arabidopsis thaliana (Mouse-ear cress)

 
8.A.138.1.2

Uncharacterized protein of 574 aas and 7 - 8 TMSs in a 2 or 3 (N-terminal) + 1 + 3 + 1 TMS (C-terminal) arrangement.

UP of Chlorella variabilis

 
8.A.138.1.3

Uncharacterized protein of 838 aas and 8 putative TMSs with 3 (N-terminal) + 5 C-terminal.

UP of Micromonas commoda

 
8.A.138.1.4

Uncharacterized protein of 463 aas and 6 TMSs with 1 at the N-terminus and 5 at the C-terminus.

UP of Selaginella moellendorffii

 
8.A.138.1.5

Uncharacterized protein of 789 aas and 6 - 8 TMSs in a 1 - 3 (N-terminal) + 5 (C-terminal) TMS arrangement.

UP of Chara braunii