8.A.189. The AP-4 Complex Accessory Subunit RUSC2 (RUSC2) Family
RUSC2 associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network. RUSC2 and WDR47 oppositely regulate kinesin-1-dependent distribution of ATG9A to the cell periphery (Guardia et al. 2021).
AP-4 complex accessory subunit, RUSC2, of 1516 aas and up to 4 TMSs in residues 1000 - 1170. RUSC2 and WDR47 oppositely regulate kinesin-1-dependent distribution of ATG9A to the cell periphery (Guardia et al. 2021).
RUSSC2 of Homo sapiens
Uncharacterized protein of 1351 aas and 3 TMSs, one N-terminal and two between residues 1100 and 1170.
UP of Varroa destructor (honeybee mite)
Uncharacterized protein of 1275 aas and possibly 0 TMSs
UP of Rotaria magnacalcarata
RUN and SH3 domain-containing protein 1 of 1536 aas and 4 or 5 TMSs between residues 1100 and 1280.
RUN & SH3 protein of Fasciola hepatica (liver fluke)
Uncharacterized protein of 1723 aas and 1 N-terminal TMS, 1 C-terminal TMS, and possibly additional TMSs in between these two.
UP of Capsaspora owczarzaki