8.A.189.  The AP-4 Complex Accessory Subunit RUSC2 (RUSC2) Family 

RUSC2 associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network. RUSC2 and WDR47 oppositely regulate kinesin-1-dependent distribution of ATG9A to the cell periphery (Guardia et al. 2021).

 


 

References:

Guardia, C.M., A. Jain, R. Mattera, A. Friefeld, Y. Li, and J.S. Bonifacino. (2021). RUSC2 and WDR47 oppositely regulate kinesin-1-dependent distribution of ATG9A to the cell periphery. Mol. Biol. Cell 32: ar25.
Examples:

TC#NameOrganismal TypeExample
8.A.189.1.1

AP-4 complex accessory subunit, RUSC2, of 1516 aas and up to 4 TMSs in residues 1000 - 1170. RUSC2 and WDR47 oppositely regulate kinesin-1-dependent distribution of ATG9A to the cell periphery (Guardia et al. 2021).

RUSSC2 of Homo sapiens

 
8.A.189.1.2

Uncharacterized protein of 1351 aas and 3 TMSs, one N-terminal and two between residues 1100 and 1170.

UP of Varroa destructor (honeybee mite)

 
8.A.189.1.3

Uncharacterized protein of 1275 aas and possibly 0 TMSs

UP of Rotaria magnacalcarata

 
8.A.189.1.4

RUN and SH3 domain-containing protein 1 of 1536 aas and 4 or 5 TMSs between residues 1100 and 1280.

RUN & SH3 protein of Fasciola hepatica (liver fluke)

 
Examples:

TC#NameOrganismal TypeExample
8.A.189.2.1

Uncharacterized protein of 1723 aas and 1 N-terminal TMS, 1 C-terminal TMS, and possibly additional TMSs in between these two.

UP of Capsaspora owczarzaki