| 8.A.253. The TMEM45A (TMEM45A) Family
Human TMEM45A has been implicated in several disease states and several forms of cancer. For example, TMEM45A is essential for hypoxia-induced chemoresistance in breast and liver cancer cells (Flamant et al. 2012), it is involved in renal fibrosis in rats by regulating the Jagged1/Notch pathway (Lan et al. 2020), it plays a role in cancer cell sensitivity to cisplatin (Schmit et al. 2019), as well as inflammatory bowel disease (IBD) and arthritis (Verma et al. 2019) as well as keratoglobus (Weiner et al. 2021), and it regulates the proliferation, migration, and invasion of glioma cells through nuclear factor kappa-B (Zhang et al. 2020).
|
| References: |
Flamant, L., E. Roegiers, M. Pierre, A. Hayez, C. Sterpin, O. De Backer, T. Arnould, Y. Poumay, and C. Michiels. (2012). TMEM45A is essential for hypoxia-induced chemoresistance in breast and liver cancer cells. BMC Cancer 12: 391.
|
Lan, J.Z., Q. Pan, Q. Tao, X. Shi, W.Z. Wang, B.W. Xu, and J.W. Luo. (2020). TMEM45A is involved in renal fibrosis in rats by regulating Jagged1/Notch pathway. Front Biosci (Landmark Ed) 25: 593-605.
|
Schmit, K., J.W. Chen, S. Ayama-Canden, M. Fransolet, L. Finet, C. Demazy, L. D'Hondt, C. Graux, and C. Michiels. (2019). Characterization of the role of TMEM45A in cancer cell sensitivity to cisplatin. Cell Death Dis 10: 919.
|
Verma, A., P. Somvanshi, S. Haque, B. Rathi, and S. Sharda. (2019). Association of Inflammatory Bowel Disease with Arthritis: Evidence from In Silico Gene Expression Patterns and Network Topological Analysis. Interdiscip Sci 11: 387-396.
|
Weiner, C., I. Hecht, A. Kotlyar, N. Shoshany, D. Zadok, U. Elbaz, F. Segev, A. Maytal, Y. Hachmo, C. Michiels, O. De Backer, N. Shomron, A. Einan-Lifshitz, and E. Pras. (2021). Association of Variants in TMEM45A With Keratoglobus. JAMA Ophthalmol 139: 1089-1095.
|
Zhang, L., F. Wu, and J. Zhao. (2020). Transmembrane protein 45A regulates the proliferation, migration, and invasion of glioma cells through nuclear factor kappa-B. Anticancer Drugs 31: 900-907.
|
| Examples: |
| TC# | Name | Organismal Type | Example |
| 8.A.253.1.1 | TMEM45A of 275 aas and 7 TMSs. See family description for activities. | | TMEM45A of Homo sapiens |
| |
| 8.A.253.1.2 | TMEM45B of 275 aas and 7 TMSs. | | TMEM45B of Homo sapiens |
| |