| 8.B.22 The P-Conotoxin Cystine Knot (P-CCK) Family
The P-CCK family of spasmodic conotoxins consists of several toxins. The structure of a synthetic construct of such a protein has been determined (1IXT; Miles et al. 2002).
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This family belongs to the Conotoxin Superfamily.
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| References: |
Miles, L.A., C.Y. Dy, J. Nielsen, K.J. Barnham, M.G. Hinds, B.M. Olivera, G. Bulaj, and R.S. Norton. (2002). Structure of a novel P-superfamily spasmodic conotoxin reveals an inhibitory cystine knot motif. J. Biol. Chem. 277: 43033-43040.
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Pi, C., J. Liu, C. Peng, Y. Liu, X. Jiang, Y. Zhao, S. Tang, L. Wang, M. Dong, S. Chen, and A. Xu. (2006). Diversity and evolution of conotoxins based on gene expression profiling of Conus litteratus. Genomics 88: 809-819.
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| Examples: |
| TC# | Name | Organismal Type | Example |
| 8.B.22.1.1 | P-type conotoxin of 88 aas | Animals (mollusca) | Conotoxin of Conus gloriamaris |
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| 8.B.22.1.2 | Conotoxin Rg9.1 of 90 aas. | Animals (Mollusca) | Conotoxin Rg9.1 of Conus regius |
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| 8.B.22.1.3 | Conotoxin of 27 aas | Animals (Mollusca) | Conotoxin of Conus amadis |
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| 8.B.22.1.4 | Conotoxin of 73 aas (Pi et al. 2006). | Animals (Mollusca) | Conotoxin of Conus litteratus |
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