8.B.22 The P-Conotoxin Cystine Knot (P-CCK) Family

The P-CCK family of spasmodic conotoxins consists of several toxins.  The structure of a synthetic construct of such a protein has been determined (1IXT; Miles et al. 2002).

This family belongs to the Conotoxin Superfamily.



Miles, L.A., C.Y. Dy, J. Nielsen, K.J. Barnham, M.G. Hinds, B.M. Olivera, G. Bulaj, and R.S. Norton. (2002). Structure of a novel P-superfamily spasmodic conotoxin reveals an inhibitory cystine knot motif. J. Biol. Chem. 277: 43033-43040.

Pi, C., J. Liu, C. Peng, Y. Liu, X. Jiang, Y. Zhao, S. Tang, L. Wang, M. Dong, S. Chen, and A. Xu. (2006). Diversity and evolution of conotoxins based on gene expression profiling of Conus litteratus. Genomics 88: 809-819.


TC#NameOrganismal TypeExample

P-type conotoxin of 88 aas

Animals (mollusca)

Conotoxin of Conus gloriamaris


Conotoxin Rg9.1 of 90 aas.

Animals (Mollusca)

Conotoxin Rg9.1 of Conus regius


Conotoxin of 27 aas

Animals (Mollusca)

Conotoxin of Conus amadis


Conotoxin of 73 aas (Pi et al. 2006).

Animals (Mollusca)

Conotoxin of Conus litteratus