8.B.39.  The Conotoxin K (CoTxJ) Family 

Some of these toxins induce excitatory symptoms in mice following intracranial administration.



Ye, M., K.K. Khoo, S. Xu, M. Zhou, N. Boonyalai, M.A. Perugini, X. Shao, C. Chi, C.A. Galea, C. Wang, and R.S. Norton. (2012). A helical conotoxin from Conus imperialis has a novel cysteine framework and defines a new superfamily. J. Biol. Chem. 287: 14973-14983.


TC#NameOrganismal TypeExample

Conotoxin im23.3 of 70 aas and 1 TMS.  It is a neurotoxin that induces excitatory symptoms in mice following intracranial administration (Ye et al. 2012). The 3-d structure of a 42 aa seqence from a similar conotoxin, conotoxin im17.a from the same organism, has been solved (PDB acc# 2LMZ).

CoTx im23.3 of Conus imperialis


Uncharacterized protein of 100 aas and 1 N-terminal TMS.

UP of Bathymodiolus septemdierum thioautotrophic gill symbiont