9.A.59 The Bacteriocin: Enterocin/Pediocin (BEP) Family

These small bacteriocins exhibit antimicrobial activity and some (ENtA and ENtB) exhibit synergism. They are cytolytic and may form pores in the membranes of target bacteria. Both Gram-positive bacteria and some Gram-negative bacteria are killed (Cintas et al., 1998; Martín-Platero et al., 2006; 2008).


 

References:

Cintas, L.M., P. Casaus, H. Holo, P.E. Hernandez, I.F. Nes, and L.S. Håvarstein. (1998). Enterocins L50A and L50B, two novel bacteriocins from Enterococcus faecium L50, are related to staphylococcal hemolysins. J. Bacteriol. 180: 1988-1994.
Martín-Platero, A.M., E. Valdivia, M. Maqueda, I. Martín-Sánchez, and M. Martínez-Bueno. (2008). Polyphasic approach to bacterial dynamics during the ripening of Spanish farmhouse cheese, using culture-dependent and -independent methods. Appl. Environ. Microbiol. 74: 5662-5673.
Martín-Platero, A.M., E. Valdivia, M. Ruíz-Rodríguez, J.J. Soler, M. Martín-Vivaldi, M. Maqueda, and M. Martínez-Bueno. (2006). Characterization of antimicrobial substances produced by Enterococcus faecalis MRR 10-3, isolated from the uropygial gland of the hoopoe (Upupa epops). Appl. Environ. Microbiol. 72: 4245-4249.
Masuda, Y., R.H. Perez, T. Zendo, and K. Sonomoto. (2016). Nutrition-adaptive control of multiple-bacteriocin production by Weissella hellenica QU 13. J Appl Microbiol 120: 70-79.
Masuda, Y., T. Zendo, N. Sawa, R.H. Perez, J. Nakayama, and K. Sonomoto. (2012). Characterization and identification of weissellicin Y and weissellicin M, novel bacteriocins produced by Weissella hellenica QU 13. J Appl Microbiol 112: 99-108.
Examples:

TC#NameOrganismal TypeExample
9.A.59.1.1

Enterocin MR10B (Enterocin I; 44 aas) (secreted without a signal sequence; Cintas et al., 1998) 

Firmicutes

Enterocin MR10B of Enterococcus faecium (D4QP39)

 
9.A.59.1.2

Pediocin L50A

Firmicutes

Pediocin L50A of Pediococcus acidilactici (Q9R4K8)

 
9.A.59.1.3

Antimicrobial Weissellicin M, WelM, of 43 aas and 1 TMS (Masuda et al. 2012). Expression of the welM gene is responsive to nutrient conditions (Masuda et al. 2016).

WelM of Weissella hellenica