| 9.A.61 The Domain of Unknown Function 3339 (DUF3339) Family
The DUF3339 domain is 68 aas in length. It is predicted to contain two transmembrane domains of 20 and 23 residues each but no cleavable signal peptide. Interestingly, several virus sequences have two tandem copies of the gene (4 predicted TMSs), and several larger proteins (enzymes; structural and regulatory proteins) have the DUF3339 domain either N- or C-terminal to the rest of these proteins. Representative sequences of the protein itself ((9.A.61.1.1 - 1.3) or fused structures (9.A.61.2.1 and 3.1) as well as duplicated viral proteins with 4 TMSs (9.A.61.4.1) are included as family members. Most if not all family members are derived from plants and related organisms.
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| References: |
Adler, L., C.S. Lau, K.M. Shaikh, K.A. van Maldegem, A.L. Payne-Dwyer, C. Lefoulon, P. Girr, N. Atkinson, J. Barrett, T.Z. Emrich-Mills, E. Dukic, M.R. Blatt, M.C. Leake, G. Peltier, C. Spetea, A. Burlacot, A.J. McCormick, L.C.M. Mackinder, and C.E. Walker. (2023). The role of BST4 in the pyrenoid of. bioRxiv.
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Adler, L., C.S. Lau, K.M. Shaikh, K.A. van Maldegem, A.L. Payne-Dwyer, C. Lefoulon, P. Girr, N. Atkinson, J. Barrett, T.Z. Emrich-Mills, E. Dukic, M.R. Blatt, M.C. Leake, G. Peltier, C. Spetea, A. Burlacot, A.J. McCormick, L.C.M. Mackinder, and C.E. Walker. (2024). Bestrophin-like protein 4 is involved in photosynthetic acclimation to light fluctuations in Chlamydomonas. Plant Physiol. [Epub: Ahead of Print]
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Hartman, J.J., J. Mahr, K. McNally, K. Okawa, A. Iwamatsu, S. Thomas, S. Cheesman, J. Heuser, R.D. Vale, and F.J. McNally. (1998). Katanin, a microtubule-severing protein, is a novel AAA ATPase that targets to the centrosome using a WD40-containing subunit. Cell 93: 277-287.
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McNally, K.P., O.A. Bazirgan, and F.J. McNally. (2000). Two domains of p80 katanin regulate microtubule severing and spindle pole targeting by p60 katanin. J Cell Sci 113(Pt9): 1623-1633.
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Xu, C., W. Su, and X. Jiang. (2020). Identification of Differentially Expressed Genes and Signaling Pathways in Glioma by Integrated Bioinformatics Analysis. J Craniofac Surg 31: 2360-2363.
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Yang, Y., A.H. Kim, T. Yamada, B. Wu, P.M. Bilimoria, Y. Ikeuchi, N. de la Iglesia, J. Shen, and A. Bonni. (2009). A Cdc20-APC ubiquitin signaling pathway regulates presynaptic differentiation. Science 326: 575-578.
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| Examples: |
| TC# | Name | Organismal Type | Example |
| 9.A.61.1.1 | DUF3339 protein of 69 aas and 2 TMSs. | | DUF3339 protein of Arabidopsis thaliana (Mouse-ear cress) |
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| 9.A.61.1.2 | Uncharacterized protein of 142 aas and 4 TMSs. | | UP of Arabidopsis thaliana (Mouse-ear cress) |
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| 9.A.61.1.3 | Uncharacterized protein of 68 aas and 2 TMSs | | UP of Prunus persica (Peach) (Amygdalus persica) |
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| Examples: |
| TC# | Name | Organismal Type | Example |
| Examples: |
| TC# | Name | Organismal Type | Example |
| 9.A.61.3.1 | Peroxidase of 368 aas and 2 C-terminal TMSs | | Peroxidase of Brassica rapa (Chinese cabbage) (Brassica pekinensis) |
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| 9.A.61.3.2 | BST4 pyrenoid protein in algae of 319 aas with one N-terminal TMS + three more moderately hydrophobic peaks, all about equidistant from each other. Bestrophin-like protein 4 is involved in photosynthetic acclimation to light fluctuations in Chlamydomonas (Adler et al. 2024). It plays a role in the concentration of CO2 in the pyrenoid of Chlamydomonas reinhardtii (Adler et al. 2023). It may be an is an ion channel involved in lumenal pH regulation, possibly by mediating bicarbonate transport across the pyrenoid tubules.
| | BST4 of Chlamydomonas reinhardtii |
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| Examples: |
| TC# | Name | Organismal Type | Example |
| 9.A.61.4.1 | Uncharacterized protein of 130 aas and 4 TMSs. | | UP of Ostreococcus tauri virus RT-2011 |
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