9.B.15 The 4 TMS YbhQ (YbhQ) Family

YbhQ of E. coli (TC# 9.B.15.1.1) is a 4 TMS protein with N- and C-termini on the inside (Daley et al., 2005). Some annotations suggest YbhQ is a heme/copper-type cytochrome/quinol oxidase subunit, but this could not be substantiated. Homologues are only found in E. coli and other closely related γ-proteobacteria. The 4 TMSs probably arose by duplication of a 2 TMS-encoding genetic element, but this suggestion needs to be confirmed. 

A second family (TC# 9.B.15.2) with 4 TMSs and similar sizes is the DUF1772 family with many members from Actinobacteria.  It is not established that these two subfamilies of 4 TMS proteins are related.


 

References:

Daley, D.O., M. Rapp, E. Granseth, K. Melen, D. Drew, and G. von Heijne. (2005). Global topology analysis of the Escherichia coli inner membrane proteome. Science 308: 1321-1323.
Examples:

TC#NameOrganismal TypeExample
9.B.15.1.1The YbhQ proteinEnteric bacteriaYbhQ of E. coli (P0AAW6)
 
9.B.15.1.2

4 TMS protein of 128 aas, YbhQ

YbhQ of Candidatus Pantoea carbekii

 
Examples:

TC#NameOrganismal TypeExample
9.B.15.2.1

Uncharacterized protein of 150 aas and 4 TMSs.

UP of Mycobacterium avium

 
9.B.15.2.10

Uncharacterized protein of 202 aas and 4 TMSs

UP of Geodermatophilus obscurus

 
9.B.15.2.11

Uncharacterized protein of 181 aas and 4 - 5 TMSs.

UP of Bdellovibrio bacteriovorus

 
9.B.15.2.2

Uncharacterized protein of the DUF1772 family of 148 aas and 4 TMSs.

UP of Streptomyces coelicolor

 
9.B.15.2.3

Uncharacterized protein of the DUF1772 family of 153 aas and 4 TMSs

UP of Mesorhizobium sp. L103C119B0

 
9.B.15.2.4

Uncharacterized protein of 147 aas and 4 TMSs

UP of Methylobacterium populi

 
9.B.15.2.5

Uncharacterized protein of 154 aas and 4 TMSs.

UP of Verrucosispora maris

 
9.B.15.2.6

Uncharacterized DUF1772 protein of 147 aas and 4 TMSs

UP of Coccomyxa subellipsoidea

 
9.B.15.2.7

Uncharacterized protein of 172 aas and 4 TMSs

UP of Thermomonospora curvata

 
9.B.15.2.8

Uncharacterized protein of 151 aas and 4 TMSs

UP of Actinoplanes sp. N902-109

 
9.B.15.2.9

Uncharacterized protein of 134 aas and 4 TMSs.

UP of Rhodopseudomonas palustris

 
Examples:

TC#NameOrganismal TypeExample