9.B.169 The Integral Membrane Protein (8 -10 TMSs) YeiB or DUF418 (YeiB) Family
The E. coli YeiB and B. subtilis YxaH proteins contain Pfam domains YeiB (the whole protein) and DUF418 (the C-terminal 4-5 TMS domain). This TC family includes proteins annotated as having DUF1624 and DUF5009 domains as well as DUF418. This family may be distantly related to TC family 9.B.97.
References:
9 or 10 TMS protein of 402 aas of unknown function with a C-terminal DUF418 domain and a full length YeiB domain, YxaH. The expression of its gene is regulated by two repressors, LmrA and QdoR, which also regulate the lmrAB operon which encodes LmrA as well as the multidrug resistance MFS drug exporter, LmrB (TC# 2.A.1.3.61) (Hirooka and Fujita 2011). Therefore, YxaH could be an MDR pump. Both of the two repressors bind flavonoids which cause them to dissociate from the DNA, promoting induction of gene expression, also consistent with YxaH being an MDR pump.
YxaH of Bacillus subtilis
Uncharacterized protein of 445 aas and 10 TMSs
UP of Thermobifida fusca
Uncharacterized protein of 309 aas and 8 TMSs
UP of Streptosporangium roseum
Uncharacterized protein of 392 aas and 10 TMSs
UP of Vibrio halioticol
YeiB of 385 aas and 8 - 10 TMSs with a C-terminal DUF418 domain. It is encoded within an operon: yeiB-folE where FolE is GTP cyclohydrolase I, the first enzyme in the biosynthesis of tetrahydrofolic acid (El Yacoubi et al. 2006). Therefore YeiB could be a transporter of a derivative in the folate biosynthetic pathway (see also TC# 9.B.169.1.1).
YeiB of E. coli
Uncharacterized protein of 421 aas and 8 TMSs.
UP of Cellulomonas fimi
Uncharacterized protein of 417 aas and 10 TMSs
UP of Sanguibacter keddieii
Uncharacterized protein of 361 aas and 10 TMSs.
UP of Psychroflexus torquis
Uncharacterized protein of 383 aas and 9 TMSs
UP of Paenibacillus mucilaginosus
Uncharacterized protein of 468 aas and 10 TMSs.
UP of Terriglobus saanensis
Uncharacterized protein of 432 aas and 10 TMSs
UP of Halobiforma lacisalsi
Uncharacterized protein of 403 aas and 10 TMSs.
UP of Nocardia brasiliensis
Uncharacterized protein of 381 aas and 11 TMSs
UP of Methanosarcina acetivorans
Uncharacterized protein of 245 aas and 7 TMSs
UP of Methanococcus maripaludis
Uncharacterized protein, putative acy transferase of 376 aas and 11 TMSs
UP of Ignavibacterium album
DUF1624 protein of 260 aas and 8 TMSs.
DUF1624 of Methanobacterium formicicum
Uncharacterized protein of 394 aas and 11 TMSs
UP of Zobellia galactanivorans
DUF1624 domain-containing protein of 389 aas and 12 TMSs in a possible 5 + 5 + 2 TMS arrangement.
DUF1624 domain protein of Moorea sp. SIO2B7
DUF418 domain-containing transporter of 376 aas and 10 TMSs
UP of Enhygromyxa salina
Uncharacterized protein of 364 aas and 10 TMSs in a 5 + 5 arrangement.
UP of Sorangiineae bacterium
Uncharacterized protein of 400 aas and 10 TMSs in an apparent 3 + 2 + 3 + 2 arrangement.
UP of Chloroflexi bacterium HGW-Chloroflexi-5
DUF418 acyltransferase family protein of 375 aas and 10 TMSs.
DUF418 protein of Lokiarchaeum sp. GC14_75
Uncharacterized acyltransferase family protein of 373 aas and 10 TMSs. similar to its paralogue with TC# 9.B.169.3.4. The two proteins are encoded by two adject genes on the archaeal chromosome.
UP of Lokiarchaeum sp. GC14_75
Heparana α-glucosaminide N-acetyltransferase, HGSNAT or MEM76. Of 663 aas and 12 TMSs in a 1 + 1 + 5 + 5 TMS arrangement. Mutations cause mucopolysaccharidosis 3C (Fan et al. 2006). This lysosomal acetyltransferase acetylates the non-reducing terminal alpha-glucosamine residue of intralysosomal heparin or heparan sulfate, converting it into a substrate for luminal alpha-N-acetyl glucosaminidase (Durand et al. 2010).
Uncharacterized DUF5009 protein of 373 aas and 10 TMSs in a 5 + 5 arrangement.
UP of Bacteroides cellulosilyticus
Uncharacterized DUF5009 protein of 442 aas and 10 TMSs in a 5 + 5 arrangement.
UP of Mobiluncus mulieris
Uncharacterized DUF3009 protein of 418 aas and 10 TMSs in a 5 + 5 arrangement.
DUF5009 protein of Singulisphaera acidiphila
Uncharacterized but putative heparan-alpha-glucosaminide N-acetyltransferase (annotation) of 395 aas and 10 TMSs.
UP of Pseudoalteromonas lipolytica
DUF5009 domain-containing proteinof 387 aas and 10 TMSs in a 5 + 5 arrangement.
DUF5009 of Prosthecobacter debontii
Uncharacteerized OpgC-domain containing protein of 425 aas and 10 TMSs.
UP of Candidatus Prometheoarchaeum syntrophicum
Uncharacterized protein of 463 aas and 10 TMSs
UP of Spirochaeta isovalerica
Uncharacterized protein of 488 aas and 10 TMSs.
UP of Candidatus Heimdallarchaeota archaeon AB_125 (marine sediment