9.B.179 The MscS/DUF475 (DUF475) Family

The DUF475 family consists of proteins primarily from Actinobacteria but possibly also Firmicutes.  They have 4 N-terminal TMSs that may be related to MARVEL domain containing proteins (TC# 1.A.64) and pantophysins (TC# 9.B.130). The hydrophilic C-terminal domain is G/Q/P-rich and redundant. 


This family belongs to the Tetraspan Junctional Complex Protein or MARVEL (4JC) Superfamily.
Examples:

TC#NameOrganismal TypeExample
9.B.179.1.1

Uncharacterized protein of 289 aas and 4 TMSs

Actinobacteria

UP of Streptomyces coelicolor

 
9.B.179.1.2

DUF475/MscS related uncharacterized protein of 272 aas and 4 N-terminal TMSs.

Actinobacteria

UP of Thermomonospora curvata

 
9.B.179.1.3

Uncharacterized protein of 336 aas and 4 TMSs

Firmicutes

UP of Streptococcus australis

 
9.B.179.1.4

Uncharacterized protein of 300 aas and 4 N-terminal TMSs

Actinobacteria

UP of Frankia sp.