9.B.310. The Putative K+ Channel Protein (K+Ch) Family A viral protein of 100 aas and 2 TMSs represent the founding member of this family. ORF A201L from chlorovirus NY-2A (accession #YP_001497468.1) was able to rescue a yeast mutant that lacked K⁺ uptake porters and channels. The results of these experiments suggested that this protein has K⁺ channel activity (Greiner et al. 2018). The positive rescue of growth by ORF A201L can be interpreted as evidence for a channel function for this protein. However, the electrophysiological characterization in HEK293 cells did not result in a robust K⁺ channel function (Greiner et al. 2018).
References:
Greiner, T., A. Moroni, J.L. Van Etten, and G. Thiel. (2018). Genes for Membrane Transport Proteins: Not So Rare in Viruses. Viruses 10:.
Examples:
TC#	Name	Organismal Type	Example
9.B.310.1.1	*Putative K+ channel protein of 100 aas and 2 TMSs. Evidence has been presented that this protein may have K+ channel activity (Greiner et al.* 2018).**		K+ channel of chlorovirus NY-2A

9.B.310.1.2	Uncharacterized protein of 79 aas and 2 TMSs		UP of Candidatus Woesearchaeota archaeon CG1_02_33_12 (groundwater metagenome)

9.B.310.1.3	Uncharacterized protein of 78 aas and 2 TMSs.		UP of Candidatus Micrarchaeota archaeon

9.B.310.1.4	Uncharacterized protein of 73 aas and 2 TMSs.		UP of Orenia marismortui