9.B.310.  The Putative K+ Channel Protein (K+Ch) Family 

A viral protein of 100 aas and 2 TMSs represent the founding member of this family. ORF A201L from chlorovirus NY-2A (accession #YP_001497468.1) was able to rescue a yeast mutant that lacked K+ uptake porters and channels. The results of these experiments suggested that this protein has K+ channel activity (Greiner et al. 2018). The positive rescue of growth by ORF A201L can be interpreted as evidence for a channel function for this protein. However, the electrophysiological characterization in HEK293 cells did not result in a robust K+ channel function (Greiner et al. 2018).



Greiner, T., A. Moroni, J.L. Van Etten, and G. Thiel. (2018). Genes for Membrane Transport Proteins: Not So Rare in Viruses. Viruses 10:.


TC#NameOrganismal TypeExample

Putative K+ channel protein of 100 aas and 2 TMSs.  Evidence has been presented that this protein may have K+ channel activity (Greiner et al. 2018).

K+ channel of chlorovirus NY-2A


Uncharacterized protein of 79 aas and 2 TMSs

UP of Candidatus Woesearchaeota archaeon CG1_02_33_12 (groundwater metagenome)


Uncharacterized protein of 78 aas and 2 TMSs.

UP of Candidatus Micrarchaeota archaeon


Uncharacterized protein of 73 aas and 2 TMSs.

UP of Orenia marismortui