9.b.313.  The 7 TMS Cir5 Domain-containing Protein (7DCP) Family

The members of the 7DCP family usually contain about 400 aas (350 - 450 aas) with 7 TMSs, although some appear to be smaller and have 5 or 6 TMSs, possibly due to incomplete sequences.  These domains can be present as fusion domains in other proteins such as MFS (FucP-like; see 2.A.1.7.25) proteins, and enzymes such as aminotransferases. When they are fused to other protein domains, they are usually the N-terminal domain. Their functions do not seem to be known, and CDD does not identify these proteins/domains although this is a huge family of eukaryotic proteins.  Members are numberous and are present primarily in fungi (Kulkarni et al. 2005).



Kulkarni, R.D., M.R. Thon, H. Pan, and R.A. Dean. (2005). Novel G-protein-coupled receptor-like proteins in the plant pathogenic fungus Magnaporthe grisea. Genome Biol 6: R24.


TC#NameOrganismal TypeExample

The Epl1/Sm1 protein of 382 aas and 7 TMSs.

Epl1/Sm1 protein of Trichoderma parareesei


4-aminobutyrate aminotransferase / (S)-3-amino-2-methylpropionate transaminase of 916 aas and 7 N-terminal TMSs.  The enzyme is C-terminal.

4-aminobutyrate aminotransferase of Talaromyces islandicus (Penicillium islandicum)


Uncharacterized protein of 356 aas and 6 or 7 N-terminal TMSs.

UP of Tolypocladium paradoxum


CFEM domain containing proteinof 313 aas and 7 TMSs.

CFEM domain protein of Macrophomina phaseolina


Uncharacterized protein of 768 aas and 7 centrally located TMSs. Quercus suber is the only plant (or non-fungal organism) that appears to encode this domain within its genome.  This suggests that it and its paralogs could be due to contaminating fungal DNA.

UP of Quercus suber


Uncharacterized protein of 371 aas and 7 TMSs.

UP of Quercus suber


PTH11 receptor of 628 aas and 7 TMSs. It is required for pathogenicity. PTH11 has an amino-terminal extracellular cysteine-rich EGF-like domain (CFEM domain), a characteristic also seen in human GPCRs. Sixty-one PTH11-related proteins were identified in M. grisea that share a common domain with homologs in Neurospora crassa and other fungi belonging to this sub-phylum of the Ascomycota (the Pezizomycotina). None was detected in other fungal groups (Basidiomycota or other Ascomycota subphyla, including yeasts) or any other eukaryote.  These proteins were suggested to be GPCRs (Kulkarni et al. 2005).

PTH11 of Magnaporthe grisea (Rice blast fungus) (Pyricularia oryzae)


Uncharacterized protein of 469 aas and 7 TMSs.

UP of Madurella mycetomatis


Uncharacterized protein of 544 aas with 7 N-terminal TMSs and a C-terminal hydrohilic domain.

UP of Epicoccum nigrum