9.B.320.  The 7 TMS Asgard Archaeal (7-AA) Family 

This family appears to consist of two distantly related subfamilies:  (1) a family of 7 (and sometimes 8) TMS archaeal proteins with an almost uniform topology of 7 TMSs.  Most of them are from the Asgard superphylum of archaea, but a few are from other archaea.  (2) the second family derives almost entirely from Actinobacteria, but a few are derived from bacteria belonging to other phyla.  While the first family consist almost entirely of small proteins with only the transmembrane domain, a few of these proteins and most of the proteins in the second family consist of the N-terminal 7 TMS domain followed by a substantial hydrophilic domain of variable size.  The latter proteins were identified as being part of this family based on BLAST seaches with iterations.  these searches also revealed the occasional occurance of G-protein receptors of Eukaryotes.


Examples:

TC#NameOrganismal TypeExample
9.B.320.1.1

UP of 244 aas and 7 TMSs.

UP of Candidatus Heimdallarchaeota archaeon AB_125

 
9.B.320.1.2

Uncharacterized protein of 250 aas and 7 TMS. 

UP of Euryarchaeota archaeon

 
9.B.320.1.3

Uncharacterized protein of 271 aas and 7 TMSs.  Isolated from a marine sediment.

UP of Candidatus Heimdallarchaeota

 
9.B.320.1.4

Uncharacterized protein of 243 aas and 7 TMSs.

UP of Candidatus Lokiarchaeota

 
9.B.320.1.5

Uncharacterized protein of 275 aas and 8 TMSs.

UP of Candidatus Lokiarchaeota

 
9.B.320.1.6

Uncharacterized protein of 277 aas and 7 TMSs.

UP of Candidatus Lokiarchaeota

 
9.B.320.1.7

Uncharacterized protein of 475 aas and 7 N-terminal TMSs with a C-terminal hydrophilic domain.

UP of Candidatus Bathyarchaeota

 
9.B.320.1.8

Uncharacterized protein of 311 aas and 7 TMSs.

UP of Candidatus Heimdallarchaeota

 
Examples:

TC#NameOrganismal TypeExample
9.B.320.2.1

Uncharacterized protein of 387 aas with 7 N-terminal TMSs followed by a hydrophilic domain.

UP of Streptomyces albulus

 
9.B.320.2.2

Uncharacterized protein of 396 aas and 7 N-terminal TMSs with a C-terminal hydrophilic domain.

UP of Streptomyces subrutilus

 
9.B.320.2.3

Uncharacterized protein of 382 aas and 7 N-terminal TMSs with a C-terminal hydrophilic domain.

UP of Amycolatopsis halophila

 
9.B.320.2.4

Uncharacteerized protein of 412 aas and 7 N-terminal TMSs plus a C-terminal hydrophilic domain.

UP of Couchioplanes caeruleus

 
9.B.320.2.5

Uncharacterized protein of 406 aas and 7 N-terminal TMSs. This protein brings up two members of subfamily 9.B.320.1, aligning asbout 280 residues, the best being 9.B.320.1.3 with an overall score of 0.002.

UP of Kutzneria buriramensis